Evidence map›Paper›PMID 36658690›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

A Bidirectional Single-Cell Migration and Retrieval Chip for Quantitative Study of Dendritic Cell Migration.

Ning Shao, Yufu Zhou, Jun Yao, Pengchao Zhang, Yanni Song, Kai Zhang, Xin Han, Bin Wang, Xuewu Liu

Open access · goldFull text read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Guiding of Cell Migration over Sloped Steps Using TiOJournal of functional biomaterials · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ning ShaoDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.ORCID 0000-0003-2534-1277
Yufu ZhouDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.
Jun YaoDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Pengchao ZhangDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.
Yanni SongDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.
Kai ZhangDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.
Xin HanDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.
Bin WangDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Xuewu LiuDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.
Houston Methodist · USThe University of Texas MD Anderson Cancer Center · US

Funding

Biophysical roles of pre-metastatic niche evolution on transport of circulating tumor cellsU01CA244107 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI KOJIC, MILOS, LEONARD, FRANSISCA · 2020 to 2024
$2.8M
Coordination of DNA repair and transcription by ubiquitin modification at DNA double strand breaksR01CA248088 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WANG, BIN · 2020 to 2024
$1.8M
NCI NIH HHS R01 CA248088NCI NIH HHS U01 CA244107NIH HHS 1R21CA191179-01A1NIH HHS U01CA244107
6 · The paper itself

Abstract

Dendritic cell (DC) migration is a fundamental step during execution of its adaptive immunity functions. Studying DC migration characteristics is critical for development of DC-dependent allergy treatments, vaccines, and cancer immunotherapies. Here, a microfluidics-based single-cell migration platform is described that enables high-throughput and precise bidirectional cell migration assays. It also allows selective retrieval of cell subpopulations that have different migratory potentials. Using this microfluidic platform, DC migration is investigated in response to different chemoattractants and inhibitors, quantitatively describe DC migration patterns and retrieve DC subpopulations of different migratory potentials for differential gene expression analysis. This platform opens an avenue for precise characterization of cell migration and potential discovery of therapeutic modulators.

Indexed as

Adaptive ImmunityDendritic CellsCell MovementImmunotherapyMicrofluidicscell retrievaldendritic cellmicrofluidicsRNA-seqsingle cell migration

Identifiers

PMID36658690
PMCPMC10015900
OpenAlexW4317512912

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read75
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.