Evidence map›Paper›PMID 36658578›Full record

ArticleMalaria journal2023

Implementing a novel capture and ligation probe-PCR method in mass screen and treatment to support malaria elimination efforts in the China-Myanmar border region.

Xiao-Dong Sun, Ya-Ling Zhao, Zu-Rui Lin, Ye Zhao, Yao-Wu Zhou, Shi-Gang Li, Xiang-Rui Guo, Peng Tian, Kai-Xia Duan, Chun-Li Ding and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 3 countries.

Xiao-Dong Sun *Yunnan Institute of Parasitic Diseases, Yunnan Provincial Collaborative Innovation Centre for Public Health and Disease Prevention and Control, Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Yunnan Provincial Centre of Malaria Research, Puer, 665000, China.
Ya-Ling Zhao *Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Zu-Rui Lin *Yunnan Institute of Parasitic Diseases, Yunnan Provincial Collaborative Innovation Centre for Public Health and Disease Prevention and Control, Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Yunnan Provincial Centre of Malaria Research, Puer, 665000, China.
Ye ZhaoInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China.
Yao-Wu ZhouYunnan Institute of Parasitic Diseases, Yunnan Provincial Collaborative Innovation Centre for Public Health and Disease Prevention and Control, Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Yunnan Provincial Centre of Malaria Research, Puer, 665000, China.
Shi-Gang LiYingjiang Centre for Disease Control and Prevention, Yingjiang, 679300, China.
Xiang-Rui GuoYingjiang Centre for Disease Control and Prevention, Yingjiang, 679300, China.
Peng TianYunnan Institute of Parasitic Diseases, Yunnan Provincial Collaborative Innovation Centre for Public Health and Disease Prevention and Control, Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Yunnan Provincial Centre of Malaria Research, Puer, 665000, China.
Kai-Xia DuanYunnan Institute of Parasitic Diseases, Yunnan Provincial Collaborative Innovation Centre for Public Health and Disease Prevention and Control, Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Yunnan Provincial Centre of Malaria Research, Puer, 665000, China.
Chun-Li DingYunnan Institute of Parasitic Diseases, Yunnan Provincial Collaborative Innovation Centre for Public Health and Disease Prevention and Control, Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Yunnan Provincial Centre of Malaria Research, Puer, 665000, China.
Qi-Yan ChenYunnan Institute of Parasitic Diseases, Yunnan Provincial Collaborative Innovation Centre for Public Health and Disease Prevention and Control, Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research, Yunnan Provincial Centre of Malaria Research, Puer, 665000, China.
Yuan SuiBrown School, Washington University, St. Louis, MO, USA.
Shen-Ning LuWHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Key Laboratory of Parasite and Vector Biology, Ministry of Science and Technology, Ministry of Health, National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, Shanghai, 200025, China.
Chris CotterMalaria Elimination Initiative, Institute for Global Health Sciences, University of California, San Francisco, CA, USA.
Duo-Quan WangBrown School, Washington University, St. Louis, MO, USA. wangdq@nipd.chinacdc.cn.
Zhi ZhengInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences; School of Basic Medicine, Peking Union Medical College, Beijing, 100005, China. zhizheng100@126.com.
Yunnan Institute of Parasitic Diseases · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNWashington University in St. Louis · USNational Institute for Parasitic Diseases · CNPeking Union Medical College Hospital · CNUniversity of California, San Francisco · US

Funding

National Major Science and Technology Projects 2018ZX10101001National Natural Science Foundation of China 81960374
6 · The paper itself

Abstract

backgroundMass screening and treatment (MSAT) for malaria elimination lacks an ideal diagnostic tool to allow sensitive and affordable test of the target population in the field. This study evaluated whether Capture and Ligation Probe-PCR (CLIP-PCR) could be used in a field MSAT in Laiza City, Myanmar.

methodsOn day 0, two dried blood spots were collected from each participant. On day 1, all samples were screened for Plasmodium in a 20 m

resultsOf 15,038 persons (65% of the total population) screened, 204 (1.36%) were CLIP-PCR positives. Among them, 188, 14, and 2 were infected with Plasmodium vivax, Plasmodium falciparum, and P. vivax/P. falciparum mix, respectively. The testing capacity was 538 persons/day, with a cost of US$0.92 /person. The proportion of submicroscopic infection was 64.7%. All positive individuals received treatment within 72 h after blood collection.

conclusionUsing CLIP-PCR in MSAT in low transmission settings can support the malaria elimination efforts in the China-Myanmar border region.

Indexed as

MalariaMalaria, FalciparumMalaria, VivaxChinaHumansMyanmarPlasmodium falciparumPlasmodium vivaxPolymerase Chain ReactionCapture and ligation probe-PCRField applicationMalariaMass screening and treatmentSubmicroscopic

Identifiers

PMID36658578
PMCPMC9854064
OpenAlexW4317503540

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.