ArticleBMC complementary medicine and therapies2023
In vitro and in vivo anthelmintic and chemical studies of Cyperus rotundus L. extracts.
Article in BMC complementary medicine and therapies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 30 citations in OpenAlex.
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- Chemical investigation and anti-trichinellosis activity of some ficus species leaves: in silico supported in vitro study.BMC complementary medicine and therapies · 2026Article
- Eugenol mitigates Trichinella spiralis-induced tissue damage via integrated antiparasitic, antioxidant, and anti-inflammatory actions.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Protective effect of Lactococcus lactis NZ9000 secreting Bcl2 against Trichinella spiralis infection in mice.BMC veterinary research · 2026Article
- Potential antioxidant and anti-inflammatory impacts of Salvia officinalis leaves extract on mice experimentally infected with Trichinella spiralis.Veterinary research communications · 2025Article
- Staphyloxanthin loaded niosomal nanocarrier augments its anthelmintic activity against Trichinella spiralis infection in mice.Scientific reports · 2025Article
- Article
- Investigating therapeutic efficacy of silymarin on intestinal and muscular phases of trichinellosis: an experimental study.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- A review on the role of deep eutectic solvents in mango (RSC advances · 2025Review
- Understanding the triacylglycerol-based carbon anabolic differentiation in Cyperus esculentus and Cyperus rotundus developing tubers via transcriptomic and metabolomic approaches.BMC plant biology · 2024Article
- In Vitro Anthelmintic Effect of Mexican Plant Extracts and Partitions AgainstPlants (Basel, Switzerland) · 2024Article
- Characterization and antioxidant activity of nano-formulated berberine and cyperus rotundus extracts with anti-inflammatory effects in mastitis-induced rats.Scientific reports · 2024Article
- Phytoconstituent analysis, anti-inflammatory, antimicrobial and anticancer effects of nano encapsulated Convolvulus arvensis L. extracts.BMC complementary medicine and therapies · 2024Article
- Impact of atorvastatin and mesenchymal stem cells combined with ivermectin on murine trichinellosis.Parasitology research · 2023Article
- The Effects of Honeysuckle (Molecules (Basel, Switzerland) · 2023Article
- Repurposing drugs to treat trichinellosis: in vitro analysis of the anthelmintic activity of nifedipine and Chrysanthemum coronarium extract.BMC complementary medicine and therapies · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTrichinellosis, a zoonosis caused by the genus Trichinella, is a widespread foodborne disease. Albendazole, one of the benzimidazole derivatives, is used for treating human trichinellosis, but with limited efficacy in killing the encysted larvae and numerous adverse effects. Cyperus rotundus L. is a herbal plant with a wide range of medicinal uses, including antiparasitic, and is frequently used in traditional medicine to treat various illnesses.
methodsLC-ESI-MS was used to identify the active phytoconstituents in the methanol extract (MeOH ext.) of the aerial parts of C. rotundus and its derivate fractions ethyl acetate (EtOAc fr.), petroleum ether (pet-ether fr.), and normal butanol (n-BuOH fr.). The in vivo therapeutic effects of C. rotundus fractions of the extracts were evaluated using the fraction that showed the most promising effect after detecting their in vitro anti-Trichinella spiralis potential.
resultsC. rotundus extracts are rich in different phytochemicals, and the LC-ESI-MS of the 90% methanol extract identified 26 phenolic compounds classified as phenolic acids, flavonoids, and organic acids. The in vitro studies showed that C. rotundus extracts had a lethal effect on T. spiralis adults, and the LC
conclusionAccordingly, C. rotundus extracts may have anti-T. spiralis potential, particularly when combined with albendazole, and they may be used as synergistic to anti-T. spiralis medication therapy.
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