ArticleNature communications2023
Sex-specificity of the C. elegans metabolome.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Neuronal Nrf/SKN-1B controls a sexually dimorphic neuroendocrine pathway for C. elegans exploratory behaviour.PLoS genetics · 2026Article
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- Untargeted metabolomics reveals divergent metabolic profiles between the predatory Arma chinensis and the Phytophagous Halyomorpha halys.Journal of insect science (Online) · 2026Article
- Leveraging open cheminformatics tools for non-targeted metabolomics analysis of C. elegans: a workflow comparison and application to strains related to xenobiotic metabolism and neurodegeneration.Analytical and bioanalytical chemistry · 2025Article
- Different gametogenesis states uniquely impact longevity in Caenorhabditis elegans.Nature communications · 2025Article
- Decoding sex-specific metabolomic biomarkers in the loggerhead sea turtle (Caretta caretta).Communications biology · 2024Article
- Accelerated hermaphrodite maturation on male pheromones suggests a general principle of coordination between larval behavior and development.Development (Cambridge, England) · 2024Article
- Lack of detectable sex differences in the mitochondrial function of Caenorhabditis elegans.BMC ecology and evolution · 2024Article
- Pheromone-based communication influences the production of somatic extracellular vesicles in C. elegans.Nature communications · 2024Article
- C. elegans males optimize mate-preference decisions via sex-specific responses to multimodal sensory cues.Current biology : CB · 2024Article
- Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans.Nature communications · 2024Article
- Decoding lifespan secrets: the role of the gonad inFrontiers in aging · 2024Review
- Repurposing degradation pathways for modular metabolite biosynthesis in nematodes.Nature chemical biology · 2023Review
- Oligonucleotide Catabolism-Derived Gluconucleosides inJournal of the American Chemical Society · 2023Article
- Article
- AbioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
Recent studies of animal metabolism have revealed large numbers of novel metabolites that are involved in all aspects of organismal biology, but it is unclear to what extent metabolomes differ between sexes. Here, using untargeted comparative metabolomics for the analysis of wildtype animals and sex determination mutants, we show that C. elegans hermaphrodites and males exhibit pervasive metabolomic differences. Several hundred small molecules are produced exclusively or in much larger amounts in one sex, including a host of previously unreported metabolites that incorporate building blocks from nucleoside, carbohydrate, lipid, and amino acid metabolism. A subset of male-enriched metabolites is specifically associated with the presence of a male germline, whereas enrichment of other compounds requires a male soma. Further, we show that one of the male germline-dependent metabolites, an unusual dipeptide incorporating N,N-dimethyltryptophan, increases food consumption, reduces lifespan, and accelerates the last stage of larval development in hermaphrodites. Our results serve as a foundation for mechanistic studies of how the genetic sex of soma and germline shape the C. elegans metabolome and provide a blueprint for the discovery of sex-dependent metabolites in other animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.