ArticleNature communications2023
Cytotoxic CD8
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
14.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
80 citing papers in PubMed, 86 citations in OpenAlex.
- CD19 CAR T cell therapy for treatment-refractory seropositive rheumatoid arthritis: a phase 1 trial.Nature medicine · 2026Trial
- Senescent-like activated naive B cells contribute to progression to clinical rheumatoid arthritis.Nature aging · 2026Article
- Metabolic switch: lymphocytes and the onset of T-cell-mediated autoimmunity.Cellular & molecular immunology · 2026Review
- A practical approach to risk stratification of incidental T-cell clonality.Blood advances · 2026Review
- Targeting Metabolic Pathways to Direct T-Cell Trafficking: Therapeutic Perspectives.Biomedicines · 2026Review
- Specificity, frequency, and phenotype of citrullinated-specific T cells vary with disease activity in rheumatoid arthritis.JCI insight · 2026Article
- Autoantibodies and T Cells Target Citrullinated and Homocitrullinated Antigens in Rheumatoid Arthritis.Immunological reviews · 2026Review
- Anti-PAD4 antibodies link autoimmunity to PAD4 with CTL-associated rheumatoid arthritis.Annals of the rheumatic diseases · 2026Article
- Identification of potential key efferocytosis-related genes in rheumatoid arthritis using machine learning.Clinical rheumatology · 2026Article
- Granzyme K CD8⁺ T cells with tissue-resident features promote intestinal inflammation in patients with Crohn's disease.Experimental & molecular medicine · 2026Article
- CSF2 drives radiation-induced lung injury by eliciting PADI4-high pathogenic neutrophils.Journal of translational medicine · 2026Article
- Cross-presentation of citrullinated antigens drives cytotoxic CD8bioRxiv : the preprint server for biology · 2026Article
- CD8Nature reviews. Cardiology · 2026Review
- Immune Cell Composition and Protein Biomarkers Correlate With PRP Treatment Outcomes in Knee Osteoarthritis.Orthopaedic journal of sports medicine · 2026Article
- Inflammatory arthritis irAE may represent a unique autoimmune disease primarily driven by T cells but likely not autoantibodies.Science advances · 2026Article
- Multidimensional single-cell analysis reveals immune dysfunction and inflammatory response in lymphatic malformations.Protein & cell · 2026Article
- Longitudinal peripheral blood multi-omic profiling in seropositive individuals identifies immune endotypes and predictive models for future rheumatoid arthritis conversion.medRxiv : the preprint server for health sciences · 2026Article
- Sex differences in disease severity and immune responses in murine and human inflammatory arthritis.Biology of sex differences · 2026Article
- Medea: An omics AI agent for therapeutic discovery.bioRxiv : the preprint server for biology · 2026Article
- Revisiting B-cell targeted therapies in rheumatoid arthritis: from paradoxical biology to deep immune reset.Frontiers in immunology · 2026Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 2 countries.
Jae-Seung Moon *Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-1983-465X
Shady Younis *Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0002-4319-1738
Nitya S RamadossDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Radhika IyerDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-1287-3995
Khushboo ShethDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID http://orcid.org/0000-0003-1681-3252
Orr SharpeDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Navin L RaoImmunology Discovery, Janssen Research and Development LLC, Spring House, PA, 19477, USA.
Stephane BecartImmunology Discovery, Janssen Research and Development LLC, San Diego, CA, 92121, USA.
Julie A CarmanImmunology Discovery, Janssen Research and Development LLC, Spring House, PA, 19477, USA.
Eddie A JamesCenter for Translational Immunology, Benaroya Research Institute, Seattle, WA, 98101, USA.ORCID http://orcid.org/0000-0002-7217-5729
Jane H BucknerCenter for Translational Immunology, Benaroya Research Institute, Seattle, WA, 98101, USA.
Kevin D DeaneDivision of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.ORCID http://orcid.org/0000-0003-2211-4861
V Michael HolersDivision of Rheumatology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Susan M GoodmanHospital for Special Surgery, New York, NY, 10021, USA.ORCID http://orcid.org/0000-0003-1197-7864
Laura T DonlinHospital for Special Surgery, New York, NY, 10021, USA.ORCID http://orcid.org/0000-0002-1428-090X
Mark M DavisInstitute for Immunity, Transplantation and Infection, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6868-657X
William H RobinsonDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA. w.robinson@stanford.edu.ORCID http://orcid.org/0000-0003-4385-704X
VA Palo Alto Health Care System · USJanssen (United States) · USBenaroya Research InstituteHospital for Special Surgery · USUniversity of Colorado Anschutz Medical Campus · USStanford University · US
Funding
Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5MThe effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2021 to 2025
$17.8MPrevention Center U01: Early Targets for Antigen-Specific Tolerance Induction in Preclinical Rheumatoid ArthritisU01AI101981 · NIAID · UNIVERSITY OF COLORADO DENVER · PI HOLERS, VERNON MICHAEL · 2012 to 2021
$6.2MUltra-Fast Epigenomic Maps for Monitoring AutoimmunityU19AI110491 · NIAID · STANFORD UNIVERSITY · PI MAECKER, HOLDEN T. · 2014 to 2018
$3.6MInvestigating Mucosal Breaks in the Initiation and Progression of Rheumatoid ArthritisR01AR078268 · NIAMS · STANFORD UNIVERSITY · PI ORANGE, DANA ELIZABETH, ROBINSON, WILLIAM H · 2021 to 2025
$3.1MLarge-Scale Characterization of Autoantibody Responses in Rheumatoid ArthritisR01AR063676 · NIAMS · STANFORD UNIVERSITY · PI ROBINSON, WILLIAM H · 2013 to 2017
$1.7MNIAID NIH HHS P01 AI153559NIAID NIH HHS U01 AI101981NIAID NIH HHS U19 AI057229NIAID NIH HHS U19 AI110491NIAMS NIH HHS R01 AR063676NIAMS NIH HHS R01 AR078268
Abstract
The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis (RA) remain poorly defined. Although increased levels of CD8
Indexed as
Arthritis, RheumatoidSynovitisAutoantibodiesAutoantigensCD8-Positive T-LymphocytesHumansReceptors, Antigen, T-CellSynovial MembraneAutoantibodiesAutoantigensReceptors, Antigen, T-Cell
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What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.