ArticleBreast (Edinburgh, Scotland)2023
Omission of axillary sentinel lymph node biopsy in early invasive breast cancer.
Article in Breast (Edinburgh, Scotland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Incorporating Percutaneous Laser Ablation for Early Breast Cancer Treatment: A Systematic Review.Technology in cancer research & treatmentPooled it
- Omission of Axillary Surgery in Patients with Negative Axillary Evaluation Integrated with LymphPET: A Prospective Clinical Study.Annals of surgical oncology · 2026Trial
- Radiofrequency Ablation for Early Stage Breast Cancer as a Potential Alternative to Partial Mastectomy: 5-Year Results from the Multiple-Center, Single-Arm, Phase 3 RAFAELO Study (NCCH1409).Annals of surgical oncology · 2026Trial
- Diagnostic performance ofEuropean journal of nuclear medicine and molecular imaging · 2026Article
- MRI-based radiomics with SHAP interpretation for preoperative prediction of upstaging in ductal carcinomaTranslational cancer research · 2026Article
- Prediction Models for Sentinel Lymph Node Metastasis in Clinically Node-Negative Breast Cancer: Validation of Existing Nomograms, Model Development, and Ensemble Evaluation.World journal of surgery · 2026Article
- Clinical Implications of the Langer's Axillary Arch Muscle in Breast Cancer Patients.Journal of breast cancer · 2026Article
- De-escalation of Axillary Surgery in Early-Stage Breast Cancer: A Comprehensive Narrative Review.Cureus · 2026Review
- Axillary surgical de-escalation after neoadjuvant therapy in breast cancer: current evidence, clinical controversies, and future directions.Frontiers in oncology · 2026Review
- A multimodal imaging-based decision tree for preoperative axillary risk stratification in breast cancer: a retrospective clinical utility analysis.American journal of cancer research · 2026Article
- Omission of sentinel lymph node biopsy in breast cancer: a survey of Brazilian breast surgeons.Einstein (Sao Paulo, Brazil) · 2026Observational
- Can intraoperative sentinel node fine-needle aspiration biopsy replace sentinel node biopsy in early-stage breast cancer patients undergoing breast-conserving surgery?Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- A comparative study of dual-layer spectral CT and 18F-FDG-PET/CT multi-quantitative parameters in the diagnosis of sentinel lymph nodes in breast cancer.Annals of nuclear medicine · 2025Article
- Management of the Axilla in Older Patients with Breast Cancer: Reassessing the Role of Sentinel Lymph Node Biopsy.Cancers · 2025Article
- Intraoperative frozen section analysis can be omitted in early breast cancer without significantly elevating reoperation rates.BMC surgery · 2025Article
- Evaluating axillary lymph node metastasis risks in breast cancer patients via Semi-ALNP: a multicenter study.EClinicalMedicine · 2025Article
- Article
- Sentinel Lymph Node Biopsy Predicts Non-Sentinel Lymph Node Metastases and Supports Omission of Axillary Lymph Node Dissection in Breast Cancer Patients.Journal of clinical medicine · 2025Article
- Omission of Axillary Surgery After Neoadjuvant Therapy in Her2-Positive Breast Cancer: Who Are the Candidates?Cancers · 2025Article
- Omitting sentinel lymph node biopsy in early breast cancer: too bold or the future?Translational breast cancer research : a journal focusing on translational research in breast cancer · 2025Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local treatment of the axilla in clinically node-negative (cN0) early breast cancer patients with routine sentinel lymph node biopsy (SLNB) is debated after publication of ACOSOG Z0011 data in 2010. Currently, prospective randomized surgical trials investigating the omission of SLNB in upfront breast-conserving surgery (BCS) and in the neoadjuvant setting, respectively. Several prospective randomized trials (SOUND, INSEMA, BOOG 2013-08, and NAUTILUS) with axillary observation alone versus SLNB in cN0 patients and primary BCS have primary objectives to evaluate oncologic safety when omitting SLNB. The Italian SOUND trial was the earliest to open in 2012 and has completed accrual in 2017. First oncologic outcome data are expected soon for SOUND and at the end of 2024 for INSEMA. Improvements in systemic treatments for breast cancer have increased the rates of pathologic complete response (pCR) in patients receiving neoadjuvant systemic therapy (NAST), offering the opportunity to de-escalate surgery in patients who have a pCR. Two prospective single-arm trials (EUBREAST-01, ASICS) include only patients with the highest likelihood of having a pCR after NAST (triple-negative or HER2-positive breast cancer) and type of surgery will be defined according to the response to NAST rather than on the classical T and N status. The ongoing trials will hopefully help us to understand whether we might take the best therapeutic decisions without the pathologic evaluation of nodal status.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.