Evidence map›Paper›PMID 36658009›Full record

ArticleThe Journal of adolescent health : official publication of the Society for Adolescent Medicine2023

Adolescent Girls and Young Women in Kenya Demonstrate Rapid STI Incidence Following First Sex: Data From a Longitudinal Cohort.

Melody Wang, Kenneth Tapia, Lynda M Oluoch, Murugi Micheni, Stacy Selke, Catherine Kiptinness, Bhavna Chohan, Anna Wald, Kenneth Ngure, Nelly R Mugo and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 2 countries.

Melody WangDepartment of Global Health, University of Washington, Seattle, Washington.
Kenneth TapiaDepartment of Global Health, University of Washington, Seattle, Washington.
Lynda M OluochDepartment of Global Health, University of Washington, Seattle, Washington; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Murugi MicheniDepartment of Global Health, University of Washington, Seattle, Washington; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya; National Syndemic Diseases Control Council, Nairobi, Kenya.
Stacy SelkeDepartment of Medicine, University of Washington, Seattle, Washington.
Catherine KiptinnessDepartment of Global Health, University of Washington, Seattle, Washington; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Bhavna ChohanDepartment of Global Health, University of Washington, Seattle, Washington; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Anna WaldDepartment of Medicine, University of Washington, Seattle, Washington; Department of Laboratory Medicine, University of Washington, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Kenneth NgureDepartment of Global Health, University of Washington, Seattle, Washington; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya; School of Public Health, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Nelly R MugoDepartment of Global Health, University of Washington, Seattle, Washington; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Alison C RoxbyDepartment of Global Health, University of Washington, Seattle, Washington; Department of Medicine, University of Washington, Seattle, Washington; Department of Epidemiology, University of Washington, Seattle, Washington; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: aroxby@uw.edu.
University of Washington · US

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI Kenneth Sherr · 1988 to 2026
$104.9M
THE PERINATAL COMPLICATIONS OF ASYMPTOMATIC GENITAL HERPES SIMPLEX VIRUSP01AI030731 · NIAID · UNIVERSITY OF WASHINGTON · PI ZHU, JIA · 1991 to 2017
$34.3M
Incident STIs in Kenyan Girls: a prospective cohort spanning sexual debutR01HD091996 · NICHD · UNIVERSITY OF WASHINGTON · PI ROXBY, ALISON CHRISTINA · 2017 to 2020
$1.4M
NIAID NIH HHS P01 AI030731NIAID NIH HHS P30 AI027757NICHD NIH HHS R01 HD091996
6 · The paper itself

Abstract

purposeAdolescent girls and young women (AGYW) are disproportionately affected by STIs. Observation of life course events can describe behavioral and biological factors associated with STI risk.

methodsSexually inexperienced AGYW aged 16-20 years in Kenya were followed for five years. Quarterly visits assessed for C. trachomatis (CT), N. gonorrhea (GC), and T. vaginalis (TV), bacterial vaginosis (BV), HSV-2, and HIV. Sexual activity was self-reported but amended if incongruent with results from STI, pregnancy, or any other testing. Cox regression and Generalized Estimating Equation models were used to determine hazard ratios (HRs) and relative risks (RRs) of STI.

resultsDuring follow-up, 293 of 400 participants reported sex, 163 AGYW experienced an STI, and 72 participants had multiple STIs. Among 163 participants that experienced an STI, there were a total of 259 visits where STIs were detected, 78% (n = 201) of which included CT. Cox regression found participants with BV had over two-fold higher risk of first STI acquisition (adjusted hazard ratio (aHR): 2.35; 95% confidence interval (CI) 1.43-3.88; p = .001). Increased risk for first STI episode was associated with a new partner (aHR: 3.16; 95% CI 1.59-6.28; p = .001). AGYW who did not disclose sexual activity had the highest risk (aHR: 3.60; 95% CI 1.93-6.70; p < .001). Condom use was low, with 21% reporting condom use with sex. GEE analysis of all STIs including incident, prevalent, and recurrent, confirmed these risk factors. DISCUSSION: During the critical years after first sex, AGYW with BV, new sexual partners, and those who did not disclose sexual activity were at highest risk for STI events, especially CT.

Indexed as

GonorrheaHIV InfectionsSexually Transmitted DiseasesVaginosis, BacterialAdolescentFemaleHumansIncidenceKenyaPregnancySexual BehaviorAdolescent girlsAdolescent healthBacterial vaginosisChlamydiaFirst sexGonorrheaKenyaSexually transmitted infection riskSexually transmitted infectionsYoung women

Identifiers

PMID36658009
PMCPMC10758297
OpenAlexW4317567881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.