Evidence map›Paper›PMID 36657189›Full record

ArticleClinical biomechanics (Bristol, Avon)2023

Body mass affects kinetic symmetry and inflammatory markers in adolescent knees during gait.

Sarah P Shultz, Ashley N Buck, Philip W Fink, Stacey M Kung, Mary J Ward, Zoltan Antal, Sherry I Backus, Andrew P Kraszewski, Howard J Hillstrom

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Sarah P ShultzKinesiology Department, Seattle University, Seattle, WA, USA. Electronic address: shultzsarah@seattleu.edu.
Ashley N BuckKinesiology Department, Seattle University, Seattle, WA, USA. Electronic address: abuck@seattleu.edu.
Philip W FinkSTAPS, Université Sorbonne Paris Nord, Bobigny, France; Institut de Biomécanique Humaine Georges Charpak, Arts et Métiers ParisTech, Paris, France. Electronic address: philipwilliam.fink@sorbonne-paris-nord.fr.
Stacey M KungSports Medicine Department, Sports Surgery Clinic, Dublin, Ireland. Electronic address: staceykung@sportssurgeryclinic.com.
Mary J WardWeill Cornell Medicine, Department of Pediatrics, New York, NY, USA. Electronic address: mjward@med.cornell.edu.
Zoltan AntalWeill Cornell Medicine, Department of Pediatrics, New York, NY, USA. Electronic address: zoa9003@med.cornell.edu.
Sherry I BackusLeon Root, MD Motion Analysis Laboratory, Rehabilitation Department, Hospital for Special Surgery (HSS), New York, NY, USA. Electronic address: backuss@hss.edu.
Andrew P KraszewskiLeon Root, MD Motion Analysis Laboratory, Rehabilitation Department, Hospital for Special Surgery (HSS), New York, NY, USA. Electronic address: kraszewskia@hss.edu.
Howard J HillstromLeon Root, MD Motion Analysis Laboratory, Rehabilitation Department, Hospital for Special Surgery (HSS), New York, NY, USA. Electronic address: hillstromh@hss.edu.
Hospital for Special Surgery · USCornell University · USSeattle University · USSorbonne Université · FRSports Surgery Clinic · IE

Funding

Clinical and Translational Science AwardUL1TR001873 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI REILLY, MUREDACH P · 2016 to 2025
$99.0M
Disparities in COVID Disease Severity and Outcomes in New York CityUL1TR002384 · NCATS · WEILL MEDICAL COLL OF CORNELL UNIV · PI JULIANNE L IMPERATO-MCGINLEY · 2017 to 2026
$86.2M
NCATS NIH HHS UL1 TR001873NCATS NIH HHS UL1 TR002384
6 · The paper itself

Abstract

backgroundEarly-onset osteoarthritis has been attributed to pro-inflammatory factors and biomechanical changes in obesity. However, research has yet to explore whether knee joint moments are asymmetrical in children with obesity and could precede the onset of knee osteoarthritis. The present study compares knee moment asymmetry between adolescents with and without obesity and examines the relationship between asymmetries and inflammatory biomarkers.

methodsTwenty-eight adolescents (13-16 years) were classified as with (n = 12) or without (n = 16) obesity. Lower extremity kinetics were measured using three-dimensional motion analysis. Bilateral knee joint moments were analyzed in the sagittal, frontal, and transverse planes across stance phase. Kinetic asymmetry was calculated between the right and left sides and represented by the R

findingsAdolescents with obesity had greater sagittal (loading, midstance) and frontal (midstance, pre-swing) plane kinetic knee asymmetry and higher concentrations of interleukin-6 and C-reactive protein. A moderately negative correlation existed between C-reactive protein and sagittal (loading, midstance) plane asymmetry, and also between interleukin-6 and frontal (pre-swing) plane asymmetry.

interpretationInflammatory response increases with greater knee joint asymmetry, suggesting knee joint damage and altered joint loading co-exist in adolescents with obesity. Increased risk to joint health may exist in sub-phases where knee joints are improperly loaded.

Indexed as

Pediatric ObesityWalkingAdolescentBiomechanical PhenomenaChildC-Reactive ProteinGaitHumansInterleukin-6Knee JointC-Reactive ProteinInterleukin-6AsymmetryChild obesityInflammatory biomarkersKineticsLower extremity

Identifiers

PMID36657189
PMCPMC9975061
OpenAlexW4315471531

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.