Evidence map›Paper›PMID 36656865›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Enhancer-promoter entanglement explains their transcriptional interdependence.

Anil K Panigrahi, David M Lonard, Bert W O'Malley

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Association and functional study ofWorld journal of psychiatry · 2025
    Article
  3. Review
  4. Liquid condensates: a new barrier to loop extrusion?Cellular and molecular life sciences : CMLS · 2025
    Review
  5. Review
  6. IntegrativebioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Anil K PanigrahiDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.
David M LonardDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.
Bert W O'MalleyDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030.ORCID 0000-0003-3332-1399
Baylor College of Medicine · US

Funding

REPRODUCTIVE HORMONES: BIOLOGICAL AND MOLECULAR ACTIONSR01HD008188 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVID M LONARD, JOHN P LYDON · 1985 to 2026
$16.3M
Translational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI CRISTIAN COARFA · 2019 to 2026
$14.7M
SEX HORMONE RECEPTOR COMPONENTS AND THE CELL GENOMER01HD007857 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVID M LONARD, JOHN P LYDON · 1985 to 2026
$14.6M
STEEL-INDUCED GENES--IDENTIFICATION AND FUNCTIONF32HD007875 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ZAMBROWICZ, BRIAN P · 1994 to 1995
–
NICHD NIH HHS F32 HD007875NICHD NIH HHS R01 HD007857NICHD NIH HHS R01 HD008188
6 · The paper itself

Abstract

Enhancers not only activate target promoters to stimulate messenger RNA (mRNA) synthesis, but they themselves also undergo transcription to produce enhancer RNAs (eRNAs), the significance of which is not well understood. Transcription at the participating enhancer-promoter pair appears coordinated, but it is unclear why and how. Here, we employ cell-free transcription assays using constructs derived from the human

Indexed as

Enhancer Elements, GeneticRNAGene Expression RegulationHumansPromoter Regions, GeneticRNA, MessengerTranscriptional ActivationTranscription, GeneticRNARNA, Messengerenhancer–promoter contacteRNAtranscription activation

Identifiers

PMID36656865
PMCPMC9942820
OpenAlexW4317476838

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.