Evidence map›Paper›PMID 36656864›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

HER2-driven breast cancer suppression by the JNK signaling pathway.

Zeynep Itah, Shanzah Chaudhry, Sithara Raju Ponny, Ozkan Aydemir, Alexandra Lee, Julie Cavanagh-Kyros, Cathy Tournier, William J Muller, Roger J Davis

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  9. Article
  10. Sequencing of high-frequency mutated genes in breast cancer (BRCA) and associated-functions analysis.International journal of clinical and experimental pathology · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Integrating integrins with the hallmarks of cancer.Matrix biology : journal of the International Society for Matrix Biology · 2024
    Review
  16. Review
  17. Article
  18. HER2-driven breast cancer suppression by the JNK signaling pathway.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Zeynep ItahProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Shanzah ChaudhryProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Sithara Raju PonnyProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Ozkan AydemirProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Alexandra LeeProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Julie Cavanagh-KyrosProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0000-0001-7003-516X
Cathy TournierDivision of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK.ORCID 0000-0002-4618-2570
William J MullerDepartment of Biochemistry, Goodman Cancer Research Center, and Faculty of Medicine, McGill University, Montreal, QC H3A 1A3, Canada.
Roger J DavisProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0000-0002-0130-1652
University of Massachusetts Chan Medical School · USMcGill University · CAUniversity of Manchester · GB

Funding

Adipose Tissue Metabolic Stress ResponsesR01DK112698 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2017 to 2025
$4.4M
Metabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6M
CIHR FDN-148373CIHR PJT-173401NIDDK NIH HHS R01 DK107220NIDDK NIH HHS R01 DK112698
6 · The paper itself

Abstract

The HER2

Indexed as

Breast NeoplasmsMAP Kinase Signaling SystemCell Line, TumorCell Transformation, NeoplasticFemaleHumansMitogen-Activated Protein Kinase 8Signal TransductionMitogen-Activated Protein Kinase 8HER2+ breast cancerintegrin α6β4JNKMAP2K4MAP2K7

Identifiers

PMID36656864
PMCPMC9942916
OpenAlexW4317437925

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.