ArticlePLoS genetics2023
An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana.
Article in PLoS genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- An atypical EF-hand domain containing resistance protein SRC4 boosts plant immunity in a calcium-enhanced manner.The Plant journal : for cell and molecular biology · 2026Article
- Two atypical resistance proteins confer plant resistance to Melanaphis sorghi in sorghum.Plant communications · 2026Article
- Broad-spectrum plant immunity: engineering pathogen protease-activated autoactive NLRs.Cell research · 2026Article
- Article
- The Landscape of Integrated Domains of Angiosperm NLR Genes Reveals Continuous Architecture Evolution of Plant Intracellular Immune Receptors.Plants (Basel, Switzerland) · 2025Article
- A CNL protein forms an NLR pair with NRCX to modulate plant immunity.Stress biology · 2025Article
- Epigenetically poised chromatin states regulateaBIOTECH · 2025Article
- Genome-wide identification and evolutionary analysis of disease resistance genes in Brassica carinata.The plant genome · 2025Article
- Activation and suppression mechanisms of the NRG1 helper NLRs.Journal of integrative plant biology · 2025Article
- A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nematodes.The Plant cell · 2025Article
- Rhomboid-mediated cleavage of the immune receptor XA21 protects grain set and male fertility in rice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Activation of an atypical plant NLR with an N-terminal deletion initiates cell death at the vacuole.EMBO reports · 2024Article
- Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome.PLoS biology · 2024Article
- NRC Immune receptor networks show diversified hierarchical genetic architecture across plant lineages.The Plant cell · 2024Article
- Subfunctionalization of NRC3 altered the genetic structure of the Nicotiana NRC network.PLoS genetics · 2024Article
- SMRT-AgRenSeq-d in potato (Horticulture research · 2023Article
- NLR receptors in plant immunity: making sense of the alphabet soup.EMBO reports · 2023Review
- Signaling and Resistosome Formation in Plant Innate Immunity to Viruses: Is There a Common Mechanism of Antiviral Resistance Conserved across Kingdoms?International journal of molecular sciences · 2023Review
- Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors.Nature genetics · 2023Article
- Plasma membrane association and resistosome formation of plant helper immune receptors.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
The NRC immune receptor network has evolved in asterid plants from a pair of linked genes into a genetically dispersed and phylogenetically structured network of sensor and helper NLR (nucleotide-binding domain and leucine-rich repeat-containing) proteins. In some species, such as the model plant Nicotiana benthamiana and other Solanaceae, the NRC (NLR-REQUIRED FOR CELL DEATH) network forms up to half of the NLRome, and NRCs are scattered throughout the genome in gene clusters of varying complexities. Here, we describe NRCX, an atypical member of the NRC family that lacks canonical features of these NLR helper proteins, such as a functional N-terminal MADA motif and the capacity to trigger autoimmunity. In contrast to other NRCs, systemic gene silencing of NRCX in N. benthamiana markedly impairs plant growth resulting in a dwarf phenotype. Remarkably, dwarfism of NRCX silenced plants is partially dependent on NRCX paralogs NRC2 and NRC3, but not NRC4. Despite its negative impact on plant growth when silenced systemically, spot gene silencing of NRCX in mature N. benthamiana leaves doesn't result in visible cell death phenotypes. However, alteration of NRCX expression modulates the hypersensitive response mediated by NRC2 and NRC3 in a manner consistent with a negative role for NRCX in the NRC network. We conclude that NRCX is an atypical member of the NRC network that has evolved to contribute to the homeostasis of this genetically unlinked NLR network.
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