ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023
Examination of potentially modifiable dementia risk factors across the adult life course: The Framingham Heart Study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Domain-specific physical activity levels and risk of dementia: a systematic review and meta-analysis.The Lancet. Public health · 2026Pooled it
- Cognitive Engagement and Dementia Risk: A Dose-Response Comparison of Nursing Home and Community Residents.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Article
- Projected Cognitive and Brain Aging Benefits of Eliminating Cardiometabolic Risks in Non-Hispanic White and Black Males - HABS-HD.Journal of racial and ethnic health disparities · 2026Article
- Japanese version of the motivation to change lifestyle and health behaviors for dementia risk reduction scale: a cross-cultural validation.International journal of public health · 2026Article
- Preserved cognitive-functional phenotype in centenarians and its association with modifiable risk factors for dementia: Results from the Colombian centenarians project.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Physical Activity Over the Adult Life Course and Risk of Dementia in the Framingham Heart Study.JAMA network open · 2025Article
- Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Life-course exposure to air pollution and the risk of dementia in the Lothian Birth Cohort 1936.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- Interaction and overall effects of underweight, low muscle mass, malnutrition, and inflammation on early-onset mild cognitive impairment in type 2 diabetes.Frontiers in aging neuroscience · 2025Article
- Associations of modifiable dementia risk factors with dementia and cognitive decline: evidence from three prospective cohorts.Frontiers in public health · 2025Article
- Observational
- Neuromuscular Dysfunction Precedes Cognitive Impairment in a Mouse Model of Alzheimer's Disease.Function (Oxford, England) · 2024Article
- A lifetime perspective on risk factors for cognitive decline with a special focus on early events.Cerebral circulation - cognition and behavior · 2024Article
- Cognitive reserve over the life course and risk of dementia: a systematic review and meta-analysis.Frontiers in aging neuroscience · 2024Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
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Abstract
introductionWe examined for associations between potentially modifiable risk factors across the adult life course and incident dementia.
methodsParticipants from the Framingham Heart Study were included (n = 4015). Potential modifiable risk factors included education, alcohol intake, smoking, body mass index (BMI), physical activity, social network, diabetes, and hypertension. Cox models were used to examine associations between each factor and incident dementia, stratified by early adult life (33-44 years), midlife (45-65 years), and late life (66-80 years).
resultsIncreased dementia risk was associated with diabetes (hazard ratio [HR] = 1.62; 95% confidence interval [CI] = 1.07-2.46) and physical inactivity (HR = 1.57; 95% CI = 1.12-2.20) in midlife, and with obesity (HR = 1.76; 95% CI = 1.08-2.87) in late life. Having multiple potential modifiable risk factors in midlife and late life was associated with greater risk. DISCUSSION: Potentially modifiable risk factors individually have limited impact on dementia risk in this population across the adult life course, although in combination they may have a synergistic effect. HIGHLIGHTS: Diabetes and physical inactivity in midlife is associated with increased dementia risk. Obesity in late life is associated with increased dementia risk. Having more potentially modifiable risk factors in midlife and late life is associated with greater dementia risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.