ArticleAmerican journal of respiratory and critical care medicine2023
Tight Glycemic Control, Inflammation, and the ICU: Evidence for Heterogeneous Treatment Effects in Two Randomized Controlled Trials.
Abstract readLetter
In one paragraph
Article in American journal of respiratory and critical care medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Biologic Mechanisms Underlying the Heterogeneous Response to Tight Glycemic Control among Differentially Inflamed Patients in the HALF-PINT Trial.American journal of respiratory and critical care medicine · 2025Trial
- Individualising blood glucose control in ICU patients: evidence and practical implementations.Critical care (London, England) · 2026Review
- Acute respiratory distress mimickers: a practical approach for intensivists.Intensive care medicine · 2026Article
- Diabetes Management Strategies in Intensive Care Settings.The Medical clinics of North America · 2026Review
- SGLT2 inhibition, uric acid and inflammation in glycemic burden-related progression of cardiac autonomic neuropathy in type 2 diabetes mellitus: insights from machine learning and mediation analysis.Frontiers in endocrinology · 2026Article
- Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS.Critical care (London, England) · 2025Article
- Evaluation of a Rapid Immunoassay for Molecular Subphenotype Classification in Pediatric Acute Cardiorespiratory Failure.Research square · 2025Article
- Moving from Observation to Explanation: Probing the Biology of Heterogeneity of Treatment Effects.American journal of respiratory and critical care medicine · 2025Article
- Development and Validation of an Electronic Health Record-Based, Pediatric Acute Respiratory Distress Syndrome Subphenotype Classifier Model.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025Article
- From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU.American journal of respiratory and critical care medicine · 2024Review
- Lung ultrasound for diagnosis and management of ARDS.Intensive care medicine · 2024Article
- Association between Age and Mortality in Pediatric and Adult Acute Respiratory Distress Syndrome.American journal of respiratory and critical care medicine · 2024Article
- Lung tissue expression of epithelial injury markers is associated with acute lung injury severity but does not discriminate sepsis from ARDS.Respiratory research · 2024Article
- Observational
- Whole blood transcriptomics identifies subclasses of pediatric septic shock.Critical care (London, England) · 2023Article
- Use of Continuous Glucose Monitors in the Hospital: The Diabetes Technology Society Hospital Meeting Report 2023.Journal of diabetes science and technology · 2023Article
- Subphenotypes Assigned to Pediatric Acute Respiratory Failure Patients Show Differing Outcomes.American journal of respiratory and critical care medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Matt S ZinterDivisions of Critical Care Medicine and Allergy, Immunology, and Bone Marrow Transplant.ORCID 0000-0003-3351-3278
Daniela MarkovicDivision of General Internal Medicine and Health Sciences Research, Department of Medicine, and.
Lisa A AsaroDepartment of Cardiology and.
Vinay M NadkarniDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Patrick S McQuillenDivision of Critical Care Medicine, Department of Pediatrics.
Pratik SinhaDivision of Clinical and Translational Research, Department of Anesthesia, Washington University, Saint Louis, Missouri.
Michael A MatthayDepartments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California.
Marc G JeschkeDivision of Plastic Surgery, Department of Surgery, and.
Michael S D AgusDivision of Medical Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts.
Anil SapruDivision of Critical Care Medicine, Department of Pediatrics, University of California, Los Angeles, Los Angeles, California.ORCID 0000-0003-1528-8249
CAF-PINT Investigators of the PALISI Network
Funding
HALF-PINT: Heart and Lung Failure - Pediatric INsulin Titration trial - CCCU01HL107681 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI AGUS, MICHAEL SD, NADKARNI, VINAY M · 2011 to 2016
$9.6MPrecision Medicine in the Acute Respiratory Distress SyndromeR35HL140026 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CALFEE, CAROLYN · 2018 to 2024
$6.8MNOVEL PARACRINE MECHANISMS FOR CELL-BASED THERAPY OF INJURED LUNGSR01HL134828 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI JI, HONG-LONG · 2017 to 2025
$3.4MPrecision Medicine in Sepsis with Critical IllnessR35GM142992 · NIGMS · WASHINGTON UNIVERSITY · PI Pratik Sinha · 2021 to 2026
$2.4MHepatic ER stress contributes to morbidity and mortality after burn injury.R01GM087285 · NIGMS · SUNNYBROOK & WOMEN'S COLL HLTH SCIS CTR · PI BOEHNING, DARREN F, JESCHKE, MARC GERHARD · 2010 to 2018
$1.9MCoagulation and Fibrinolysis in Pediatric Insulin Titration TrialR01HL114484 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAPRU, ANIL · 2012 to 2015
$1.6MBurn induces hypermetabolism via browning of the white adipose tissueR01GM133961 · NIGMS · SUNNYBROOK RESEARCH INSTITUTE · PI JESCHKE, MARC GERHARD · 2020 to 2023
$1.3MPathobiologic Transcriptional Signatures of Pulmonary Complications in Pediatric Hematopoietic Cellular TransplantationK23HL146936 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZINTER, MATTHEW SCOTT · 2020 to 2024
$980kNHLBI NIH HHS K23 HL146936NHLBI NIH HHS K23HL146936NHLBI NIH HHS R01 HL114484NHLBI NIH HHS R01HL114484NHLBI NIH HHS R01 HL134828NHLBI NIH HHS R01HL134828NHLBI NIH HHS R35 HL140026NHLBI NIH HHS R35HL140026NHLBI NIH HHS U01 HL107681NHLBI NIH HHS U01HL107681NIGMS NIH HHS R01 GM087285NIGMS NIH HHS R01GM087285NIGMS NIH HHS R01 GM133961NIGMS NIH HHS R01GM133961NIGMS NIH HHS R35 GM142992NIGMS NIH HHS R35GM142992
Abstract
PubMed holds no abstract for this paper.
Indexed as
Blood GlucoseGlycemic ControlHumansHypoglycemic AgentsInflammationInsulinIntensive Care UnitsRandomized Controlled Trials as TopicBlood GlucoseHypoglycemic AgentsInsulin
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.