ReviewCurrent treatment options in oncology2023
Management of Fatigue in Patients with Advanced Cancer.
Review in Current treatment options in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Dexamethasone for 12 weeks for reducing fatigue in patients receiving palliative chemotherapy: A Phase 3, Placebo-Controlled, Randomized Controlled Trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Trial
- Methylphenidate versus placebo for fatigue in patients with advanced cancer: the MePFAC randomised controlled trial.Health technology assessment (Winchester, England) · 2025Trial
- Fatigue, physical function, and the context of social vulnerability for older adults with cancer.Journal of geriatric oncology · 2025Trial
- Methylphenidate Versus Placebo for Treating Fatigue in Patients With Advanced Cancer: Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Trial
- Time toxicity among patients with cancer: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Individualized Physiotherapy Improves Quality of Life and Symptom Burden in Advanced Cancer: A Quasi-Experimental Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026Article
- A pharmacoeconomic evaluation of aprepitant injection versus aprepitant capsules for the prevention of CINV caused by moderately and highly emetogenic chemotherapy.Frontiers in pharmacology · 2026Article
- The Symptom Clusters and Core Symptoms in Patients with Lung Cancer After Surgery: A Longitudinal Network Analysis.Patient preference and adherence · 2026Article
- Network analysis of multidimensional symptom experience among postoperative esophageal cancer survivors.Health and quality of life outcomes · 2025Article
- Network analysis of fatigue symptoms in Chinese patients with advanced cancer.Asia-Pacific journal of oncology nursing · 2025Article
- The Role of Psychological Distress on Health-Related Quality of Life, Fatigue, and Pain in Adults With Pulmonary Hypertension.Pulmonary circulation · 2025Article
- Relationship between physical activity and quality of life among patients with respiratory and digestive system cancer during and outside the COVID-19 pandemic.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- Effects of Jianpi therapy for cancer-related fatigue:a meta-analysis of randomized controlled trials.Frontiers in oncology · 2025Article
- Putting Methylphenidate for Cancer-Related Fatigue to Rest?Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Article
- Feasibility of a physical exercise intervention for patients on a palliative care unit: a critical analysis.BMC palliative care · 2024Article
- Comparing the sensitivity of fatigue and sleep disturbance assessment tools in women with advanced cancer undergoing chemotherapy.Asia-Pacific journal of oncology nursing · 2024Article
- Mental health needs in cancer - a call for change.Future healthcare journal · 2023Article
- Observational Study on the Effectiveness of L-Arginine Plus Vitamin C in the Management of Cancer-related Fatigue.In vivo (Athens, Greece)Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
opinion statementFatigue is a common and distressing symptom experienced by patients with cancer. It is most common in patients with locally advanced or metastatic incurable disease. It can have profound effects on quality-of-life and physical functioning. In addition to general supportive measures (directed at tackling contributory conditions and comorbidities), a variety of specific interventions have been developed which can be broadly categorised as physical therapies, psychological therapies or medication. There is some evidence that each of these approaches can have benefits in patients with earlier stage disease, those undergoing active treatment and in cancer survivors. The best evidence is for aerobic exercise, yoga, cognitive-behavioural therapy (CBT) and psycho-educational interventions. Less strong evidence supports the use of medications such as methylphenidate or ginseng. In patients with advanced disease, it is likely that the mechanisms of fatigue or the factors contributing to fatigue maintenance may be different. Relatively fewer studies have been undertaken in this group and the evidence is correspondingly weaker. The authors recommend the cautious use of aerobic exercise (e.g. walking) in those who are still mobile. The authors advise considering the use of psycho-educational approaches or CBT in those patients who are able to engage in such forms of therapy. In patients near the end-of-life, the authors advise use of dexamethasone (short-term use) and other pharmacological treatments only on the basis of a clinical trial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.