Evidence map›Paper›PMID 36656498›Full record

ArticleMolecular biotechnology2023

Mechanism of Resveratrol Improving Ischemia-Reperfusion Injury by Regulating Microglial Function Through microRNA-450b-5p/KEAP1/Nrf2 Pathway.

JiaHui Liu, JinYu Chen, JinFeng Zhang, Yu Fan, ShiJun Zhao, BaoJun Wang, Po Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

JiaHui Liu *Department of Neurology, Inner Mongolia Baotou Central Hospital, No. 61 Ring Roads, Donghe District, Baotou, 014040, Inner Mongolia Autonomous Region, China.
JinYu Chen *Department of Neurology, Inner Mongolia Baotou Central Hospital, No. 61 Ring Roads, Donghe District, Baotou, 014040, Inner Mongolia Autonomous Region, China.
JinFeng ZhangDepartment of Neurology, Inner Mongolia Baotou Central Hospital, No. 61 Ring Roads, Donghe District, Baotou, 014040, Inner Mongolia Autonomous Region, China.
Yu FanDepartment of Neurology, Inner Mongolia Baotou Central Hospital, No. 61 Ring Roads, Donghe District, Baotou, 014040, Inner Mongolia Autonomous Region, China.
ShiJun ZhaoDepartment of Neurology, Inner Mongolia Baotou Central Hospital, No. 61 Ring Roads, Donghe District, Baotou, 014040, Inner Mongolia Autonomous Region, China.
BaoJun WangDepartment of Neurology, Inner Mongolia Baotou Central Hospital, No. 61 Ring Roads, Donghe District, Baotou, 014040, Inner Mongolia Autonomous Region, China.
Po WangDepartment of Neurology, Inner Mongolia Baotou Central Hospital, No. 61 Ring Roads, Donghe District, Baotou, 014040, Inner Mongolia Autonomous Region, China. wp_wangpo@hotmail.com.ORCID http://orcid.org/0000-0002-3576-8576
Baotou Central Hospital · CN

Funding

Natural Science Foundation of Inner Mongolia No. 2021 MS08042
6 · The paper itself

Abstract

Alterations in the M1/M2 polarization phenotype significantly affect disease progression. Antioxidant and anti-inflammatory protective effects of resveratrol (Res) have been demonstrated. This paper tested the hypothesis that Res could protect against cerebral ischemia-reperfusion injury (CI/RI) by modulating microglial polarization via the miR-450b-5p/KEAP1/Nrf2 pathway. Rats were first treated with Res and adenovirus that interfered with miR-450b-5p or KEAP1, and then established a middle cerebral artery occlusion-reperfusion model using modified nylon sutures. Rats were then evaluated for neurological and behavioral functions, and markers of M2 microglia were detected by immunofluorescence staining. Additionally, the signature patterns of miR-450b-5p, KEAP1, and Nrf2 were determined. The collected data demonstrated that Res exerted neuroprotective effects in CI/RI by promoting microglial M2 polarization. Additionally, Res could regulate the Nrf2 pathway by targeting KEAP1 by up-regulating miR-450b-5p. Up-regulating miR-450b-5p or down-regulating KEAP1 could further promote the protective effect of Res, while down-regulating miR-450b-5p or up-regulating KEAP1 worked oppositely. Our study demonstrates that Res exerts neuroprotective effects on microglial M2 polarization through the miR-450b-5p/KEAP1/Nrf2 pathway during CI/RI.

Indexed as

MicroRNAsNeuroprotective AgentsReperfusion InjuryAnimalsKelch-Like ECH-Associated Protein 1MicrogliaNF-E2-Related Factor 2RatsResveratrolKEAP1 protein, ratKelch-Like ECH-Associated Protein 1MicroRNAsNeuroprotective AgentsNF-E2-Related Factor 2ResveratrolCerebral ischemia–reperfusion injuryKEAP1MicrogliamicroRNA-450b-5pNrf2-signaling pathwayResveratrol

Identifiers

PMID36656498
OpenAlexW4317423834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.