ArticleDrug safety2023
Development and Validation of ICD-10-CM-based Algorithms for Date of Last Menstrual Period, Pregnancy Outcomes, and Infant Outcomes.
Article in Drug safety, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Algorithms to Identify Major Congenital Malformations in Routinely Collected Healthcare Data: A Systematic Review.Drug safety · 2026Pooled it
- Systematic Review of Avian Influenza Virus Infection and Outcomes during Pregnancy.Emerging infectious diseases · 2025Pooled it
- Systematic review of validated case definitions to identify hypertensive disorders of pregnancy in administrative healthcare databases.Open heart · 2023Pooled it
- Developing a Hierarchical Algorithm to Identify Pregnancies and Determine Gestational Age from Nationwide Linked Health Data in Taiwan.Drug safety · 2026Article
- Validation of Claims-Based Algorithms for Identifying Congenital Urinary Tract, Genital, Gastrointestinal, and Musculoskeletal Malformations.Pharmacoepidemiology and drug safety · 2026Article
- Identifying Pregnancies in Population-Based Data Sources: Development and Application of the ConcePTION Pregnancy Algorithm.Pharmacoepidemiology and drug safety · 2026Article
- Clinical burden of classic congenital adrenal hyperplasia and glucocorticoid-related complications: a claims analysis.Journal of the Endocrine Society · 2026Article
- Risk of Fetal Exposure to Teratogenic Medications: Development of Evidence for the Teratogenic Risk Impact and Mitigation (TRIM) Tool.Drug safety · 2026Article
- Pregnancy identification method as a source of bias in studies of prenatal exposures using real-world data.American journal of epidemiology · 2026Article
- Machine Learning Estimation of Gestational Age at Delivery Using Linked Mother-Infant Electronic Health Records Across Two Health Systems.medRxiv : the preprint server for health sciences · 2026Article
- Identifying pregnancies in routinely collected health data: a scoping review of methods.BMC medical informatics and decision making · 2026Article
- Pregnancy Outcomes Associated With Anemia in the First Trimester and Anemia Resolution by Late Pregnancy.Obstetrics and gynecology · 2026Article
- Sequential Safety Surveillance of RSVpreF Vaccination During Pregnancy Early in the Postapproval Period.JAMA network open · 2026Article
- Characterizing Perinatal Treatment Patterns and Outcomes in Myasthenia Gravis.Muscle & nerve · 2026Article
- Validation of ICD-9-CM and ICD-10-CM Diagnosis Codes for Identifying Preterm Birth and Low Birthweight Infants in Florida Birth Hospitalizations, 2008-2018.Journal of registry management · 2026Article
- The AMerican PREGNANcy Mother-Child CohorT: description and prevalence of baseline outcomes and medication dispensing.Frontiers in pharmacology · 2025Article
- Maternal influenza vaccination and associated risk of fetal loss: A claims-based prospective cohort study.Vaccine · 2024Article
- Pregnancy episodes in All of Us: harnessing multi-source data for pregnancy-related research.Journal of the American Medical Informatics Association : JAMIA · 2024Article
- Discover overlooked complications after preeclampsia from three real-world medical record datasets of over 100,000 pregnancies.medRxiv : the preprint server for health sciences · 2024Article
- Use of the Sentinel System to Examine Medical Product Use and Outcomes During Pregnancy.Drug safety · 2024Review
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
INTRODUCTION AND
objectiveValidation studies of algorithms for pregnancy outcomes based on International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) codes are important for conducting drug safety research using administrative claims databases. To facilitate the conduct of pregnancy safety studies, this exploratory study aimed to develop and validate ICD-10-CM-based claims algorithms for date of last menstrual period (LMP) and pregnancy outcomes using medical records.
methodsUsing a mother-infant-linked claims database, the study included women with a pregnancy between 2016-2017 and their infants. Claims-based algorithms for LMP date utilized codes for gestational age (Z3A codes). The primary outcomes were major congenital malformations (MCMs) and spontaneous abortion; additional secondary outcomes were also evaluated. Each pregnancy outcome was identified using a claims-based simple algorithm, defined as presence of ≥ 1 claim for the outcome. Positive predictive values (PPV) and 95% confidence intervals (CI) were calculated.
resultsOverall, 586 medical records were sought and 365 (62.3%) were adjudicated, including 125 records each for MCMs and spontaneous abortion. Last menstrual period date was validated among maternal charts procured for pregnancy outcomes and fewer charts were adjudicated for the secondary outcomes. The median difference in days between LMP date based on Z3A codes and adjudicated LMP date was 4.0 (interquartile range: 2.0-10.0). The PPV of the simple algorithm for spontaneous abortion was 84.7% (95% CI 78.3, 91.2). The PPV for the MCM algorithm was < 70%. The algorithms for the secondary outcomes pre-eclampsia, premature delivery, and low birthweight performed well, with PPVs > 70%.
conclusionsThe ICD-10-CM claims-based algorithm for spontaneous abortion performed well and may be used in pregnancy studies. Further algorithm refinement for MCMs is needed. The algorithms for LMP date and the secondary outcomes would benefit from additional validation in a larger sample.
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