SynthesisJournal of patient-reported outcomes2023
A critical evaluation of the content validity of patient-reported outcome measures assessing health-related quality of life in children with cancer: a systematic review.
Synthesis in Journal of patient-reported outcomes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Measures of identity in adolescents/young adults with long-term physical health conditions: a systematic review.Journal of pediatric psychology · 2026Pooled it
- Pooled it
- Measurement of compassion fatigue in animal health care professionals: a systematic review of available instruments and their content validity.Frontiers in veterinary science · 2024Pooled it
- Health-Related Quality of Life in Children with Acute Leukaemia and Central Nervous System Tumours: Current Evidence and Future Directions.Children (Basel, Switzerland) · 2026Review
- Overall Good Quality of Life Reported by Survivors of Childhood Hodgkin Lymphoma in Sweden and Finland.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Cancer-related fatigue in children during treatment: a 5-year cohort study of daily patient-reported outcomes with clinical implications.EClinicalMedicine · 2025Article
- Patient-reported Outcome Measures in Pediatric Orthopaedics.Journal of the Pediatric Orthopaedic Society of North America · 2025Review
- Validity of the Connor Davidson Resilience Scale (CD-RISC) in adolescents and young adults in Sweden: a think aloud approach combined with a Rasch analysis.Health and quality of life outcomes · 2025Article
- "I'm learning to live after cancer and its treatment": Exploring the challenges of cancer survivorship in Arkansas.SSM. Qualitative research in health · 2025Article
- Commentary: Without Values, Complexity is Reduced to Mathematics.Journal of evaluation in clinical practice · 2025Article
- Article
- Rasch analysis of a patient-reported outcome measure for self-perceived health among psychiatric patients in Denmark.BMJ open quality · 2024Article
- Development and psychometric testing of a pediatric chronic graft-versus-host disease symptom scale: protocol for a two-phase, mixed methods study.Frontiers in psychology · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith increasing survival rates in pediatric oncology, the need to monitor health-related quality of life (HRQOL) is becoming even more important. However, available patient-reported outcome measures (PROMs) have been criticized. This review aims to systematically evaluate the content validity of PROMs for HRQOL in children with cancer.
methodsIn December 2021, a systematic literature search was conducted in PubMed. PROMs were included if they were used to assess HRQOL in children with cancer and had a lower age-limit between 8 and 12 years and an upper age-limit below 21 years. The COSMIN methodology for assessing the content validity of PROMs was applied to grade evidence for relevance, comprehensiveness, and comprehensibility based on quality ratings of development studies (i.e., studies related to concept elicitation and cognitive interviews for newly developed questionnaires) and content validity studies (i.e., qualitative studies in new samples to evaluate the content validity of existing questionnaires).
resultsTwelve PROMs were included. Due to insufficient patient involvement and/or poor reporting, the quality of most development studies was rated 'doubtful' or 'inadequate'. Few content validity studies were available, and these were mostly 'inadequate'. Following the COSMIN methodology, evidence for content validity was 'low' or 'very low' for almost all PROMs. Only the PROMIS Pediatric Profile had 'moderate' evidence. In general, the results indicated that the PROMs covered relevant issues, while results for comprehensiveness and comprehensibility were partly inconsistent or insufficient. DISCUSSION: Following the COSMIN methodology, there is scarce evidence for the content validity of available PROMs for HRQOL in children with cancer. Most instruments were developed before the publication of milestone guidelines and therefore were not able to fulfill all requirements. Efforts are needed to catch up with methodological progress made during the last decade. Further research should adhere to recent guidelines to develop new instruments and to strengthen the evidence for existing PROMs.
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