Evidence map›Paper›PMID 36656405›Full record

ArticleFolia microbiologica2023

Examining the effects of BRG1 over-expression on Candida albicans strains growing as pseudohyphae.

Joseph Mariscal, Derek P Thomas, Ian A Cleary

Abstract read
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In one paragraph

Article in Folia microbiologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph MariscalDepartment of Biomedical Sciences, Grand Valley State University, One Campus Drive, Allendale, MI, 49401, USA.
Derek P ThomasDepartment of Biomedical Sciences, Grand Valley State University, One Campus Drive, Allendale, MI, 49401, USA.
Ian A ClearyDepartment of Biomedical Sciences, Grand Valley State University, One Campus Drive, Allendale, MI, 49401, USA. clearyia@gvsu.edu.ORCID http://orcid.org/0000-0002-3958-431X
Grand Valley State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogen Candida albicans is pleiomorphic and grows in yeast and filamentous forms but the relationship between the regulation of different filamentous forms is unclear. BRG1 encodes a DNA binding protein which is an important regulator of morphology. Mutants lacking BRG1 grow as yeast under all conditions tested and over-expressing BRG1 drives hyphal growth even in the absence of inducing signals. A number of genetic mutants in repressors of filamentation form pseudohyphae under yeast conditions and some of these mutants can form hyphae under hypha-inducing conditions. This study examines the position of BRG1 in the regulatory networks that govern filamentation by examining the effect of over-expressing BRG1 in pseudohyphal mutants.

Indexed as

Candida albicansFungal ProteinsGene Expression Regulation, FungalHyphaeTranscription FactorsFungal ProteinsTranscription FactorsBRG1Candida albicansNRG1RFG1TUP1 pseudohyphae

Identifiers

PMID36656405
OpenAlexW4317475703

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.