Evidence map›Paper›PMID 36656336›Full record

ArticlePsychopharmacology2023

Place conditioning in humans: opportunities for translational research.

Seetha Krishnan, Rick A Bevins, Harriet de Wit

Abstract read
In one paragraph

Article in Psychopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Context features influence alcohol reward and motivation.Alcohol, clinical & experimental research · 2026
    Article
  3. Kappa opioid receptor control of motivated behavior revisited.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seetha KrishnanDepartment of Neurobiology and Institute for Neuroscience, University of Chicago, Chicago, IL, 60637, USA.
Rick A BevinsDepartment of Psychology, University of Nebraska - Lincoln, Lincoln, NE, 68588-0308, USA.
Harriet de WitDepartment of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, 60637, USA. hdew@uchicago.edu.

Funding

Testing the Efficacy of Ibudilast to Attenuate Meth-seeking and Associated Synaptic Inflammation at the Synapse (TEAMS)P20GM130461 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI KIMBERLY A TYLER · 2019 to 2026
$20.6M
Determinants of Drug Preference in Humans--Administrative SupplementR01DA002812 · NIDA · UNIVERSITY OF CHICAGO · PI DE WIT, HARRIET · 1985 to 2024
$10.6M
Integrative Training in the Neurobiology of Addictive BehaviorsT32DA043469 · NIDA · UNIVERSITY OF CHICAGO · PI Donald Hedeker, Xiaoxi Zhuang · 2017 to 2026
$3.8M
Interoceptive conditioning with nicotine: Changes in abuse liabilityR01DA046109 · NIDA · UNIVERSITY OF NEBRASKA LINCOLN · PI BEVINS, RICK A · 2018 to 2022
$1.8M
NIDA NIH HHS R01 DA002812NIDA NIH HHS R01 DA046109NIDA NIH HHS T32 DA043469NIDA NIH HHS T32DA043469NIGMS NIH HHS P20 GM130461
6 · The paper itself

Abstract

rationaleTranslational research, especially research that bridges studies with humans and nonhuman species, is critical to advancing our understanding of human disorders such as addiction. This advancement requires reliable and rigorous models to study the underlying constructs contributing to the maladaptive behavior.

objectiveIn this commentary, we address some of the challenges of conducting translational research by examining a single procedure, place conditioning. Place conditioning is commonly used with laboratory animals to study the conditioned rewarding effects of drugs, and recent studies indicate that a similar procedure can be used in humans.

resultsWe discuss the opportunities and challenges of making the procedure comparable across species, as well as discuss the benefits of more systematically applying the procedure to humans.

conclusionWe argue that the capacity of humans to report verbally on their internal experiences (perceptions, affective states, likes and dislikes) add an important dimension to the understanding of the procedures used in laboratory animals.

Indexed as

Behavior, AddictiveTranslational Research, BiomedicalAnimalsEmotionsHumansRewardConditioned drug effectsPavlovian place conditioningSubstance abuseTranslational research

Identifiers

PMID36656336
PMCPMC10949408

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.