ArticleeLife2023
Control of craniofacial development by the collagen receptor, discoidin domain receptor 2.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 19 citations in OpenAlex.
- Roles of integrin β1 and discoidin domain receptor 2 in cranial regeneration and skeletal progenitor cell function.International journal of oral science · 2026Article
- The tectum transversum maintains patency of the developing coronal suture.Development (Cambridge, England) · 2026Article
- Evidence that disruption of Discoidin domain receptor 2 contributes to palate malformations through effects on the extracellular matrix.Human molecular genetics · 2026Article
- Discoidin Domain Receptor 2 Is Required for Tooth Extraction Socket Healing.Journal of dental research · 2026Article
- Decoding collagen cues: the interplay of integrins and discoidin domain receptors in health and disease.Journal of biomedical science · 2026Review
- Article
- Injury-induced niche factors Cxcl12 and Shh/Ihh coordinate suture stem cell activation during calvarial bone regeneration.Science signaling · 2025Article
- Article
- [Advances in the Study of Calvarial Stem Cells].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Review
- Discoidin domain receptor 2 is an important modulator of BMP signaling during heterotopic bone formation.Bone research · 2025Article
- Exposure to maternal nicotine in utero and/or via lactation alters craniofacial development in mice.PloS one · 2025Article
- Synthetic helical peptides on nanofibers to activate cell-surface receptors and synergistically enhance critical-sized bone defect regeneration.Bioactive materials · 2025Article
- Are osteoblasts multiple cell types? A new diversity in skeletal stem cells and their derivatives.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Review
- Craniofacial chondrogenesis in organoids from human stem cell-derived neural crest cells.iScience · 2024Article
- Extracellular matrix dynamics: A key regulator of cell migration across length-scales and systems.Current opinion in cell biology · 2024Review
- Dual stem-cell populations interact in the skull.Nature · 2023Article
- Synthetic peptides activating discoidin domain receptor 2 and collagen-binding integrins cooperate to stimulate osteoblast differentiation of skeletal progenitor cells.Acta biomaterialia · 2023Article
- Discoidin domain receptors; an ancient family of collagen receptors has major roles in bone development, regeneration and metabolism.Frontiers in dental medicine · 2023Article
- Cranial Base Synchondrosis: Chondrocytes at the Hub.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 2 countries.
Fatma F MohamedDepartment of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, United States.
Chunxi Ge *Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, United States.
Shawn A Hallett *Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, United States.ORCID https://orcid.org/0000-0003-1472-7502
Alec C BancroftCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, United States.
Randy T CowlingDivision of Cardiovascular Medicine, University of California, San Diego, San Diego, United States.
Noriaki OnoDepartment of Diagnostic and Biomedical Sciences, University of Texas Health Science Center at Houston School of Dentistry, Houston, United States.ORCID https://orcid.org/0000-0002-3771-8230
Abdul-Aziz BinrayesDepartment of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Barry GreenbergDivision of Cardiovascular Medicine, University of California, San Diego, San Diego, United States.
Benjamin LeviCenter for Organogenesis and Trauma, Department of Surgery, University of Texas Southwestern, Dallas, United States.
Vesa M KaartinenDepartment of Biologic & Materials Science, University of Michigan School of Dentistry, Ann Arbor, United States.
Renny T FranceschiDepartment of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, United States.ORCID https://orcid.org/0000-0003-1405-2541
University of Michigan · USOrganogenesis (United States) · USUniversity of California San Diego · USKing Saud University · SAThe University of Texas Health Science Center at Houston · US
Funding
Structure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MYR01DE011723 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 1995 to 2017
$5.3MImpacts of mechanosensation and matrix architecture on cell fate specification in traumatic heterotopic ossification - diversity supplementR01AR078324 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI LEVI, BENJAMIN · 2021 to 2025
$2.4MDiscoidin Domain Receptor 2, β1 Integrins and ECM Control of Bone FormationR01DE029465 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2021 to 2025
$2.4MDiscoidin domain receptor 2, a novel regulator of bone regenerationR21DE029012 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2019 to 2020
$429kMAP KINASE REGULATION OF OSTEOBLAST FUNCTIONR56DE011723 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2007 to 2007
$286kNIAMS NIH HHS P30 AR069620NIAMS NIH HHS P30AR069620NIAMS NIH HHS R01 AR078324NIAMS NIH HHS R01AR078324NIDCR NIH HHS R01 DE011723NIDCR NIH HHS R01 DE029465NIDCR NIH HHS R01DE029465NIDCR NIH HHS R01DE11723NIDCR NIH HHS R21 DE029012NIDCR NIH HHS R21DE029012NIDCR NIH HHS R56 DE011723
Abstract
Development of the craniofacial skeleton requires interactions between progenitor cells and the collagen-rich extracellular matrix (ECM). The mediators of these interactions are not well-defined. Mutations in the discoidin domain receptor 2 gene (
Indexed as
Discoidin Domain Receptor 2AnimalsCartilageChondrocytesCollagenHumansMiceReceptors, CollagenCollagenDdr2 protein, mouseDiscoidin Domain Receptor 2Receptors, Collagencell biologycranial suturecraniofacial growthdevelopmental biologyextracellular matrixmousesynchondrosis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.