Evidence map›Paper›PMID 36656016›Full record

ArticlemBio2023

Robert J Cain, Mariela Scortti, Héctor J Monzó, José A Vázquez-Boland

Open access · goldAbstract read
In one paragraph

Article in mBio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Robert J CainMicrobial Pathogenesis Laboratory, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Mariela ScorttiMicrobial Pathogenesis Laboratory, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, Scotland, United Kingdom.
Héctor J MonzóMicrobial Pathogenesis Laboratory, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, Scotland, United Kingdom.
José A Vázquez-BolandMicrobial Pathogenesis Laboratory, Infection Medicine, Edinburgh Medical School (Biomedical Sciences), University of Edinburgh, Edinburgh, Scotland, United Kingdom.ORCID 0000-0003-4521-5972
University of Edinburgh · GB

Funding

Wellcome TrustWellcome Trust WT074020MA
6 · The paper itself

Abstract

Rapid phagosomal escape mediated by listeriolysin O (LLO) is a prerequisite for Listeria monocytogenes intracellular replication and pathogenesis. Escape takes place within minutes after internalization from vacuoles that are negative to the early endosomal Rab5 GTPase and positive to the late endosomal Rab7. Using mutant analysis, we found that the listerial invasin InlB was required for optimal intracellular proliferation of L. monocytogenes. Starting from this observation, we determined in HeLa cells that InlB promotes early phagosomal escape and efficient Rab7 acquisition by the

Indexed as

ListeriaListeria monocytogenesBacterial ProteinsCell ProliferationClass III Phosphatidylinositol 3-KinasesHeLa CellsHemolysin ProteinsHumansPhosphatidylinositol 3-Kinasesrab7 GTP-Binding ProteinsVacuolesBacterial ProteinsClass III Phosphatidylinositol 3-KinasesHemolysin ProteinsPhosphatidylinositol 3-Kinasesrab7 GTP-Binding Proteinsrab7 GTP-binding proteins, humanclass III PI3Kendocytic traffickingInlBinternalinsintracellular parasitismintracellular proliferationintracellular survivalListeria-containing vacuoleListeria monocytogenesListeria virulencephagosome maturationphosphatidylinositol 3-phosphatephosphoinositide 3-kinaseRab5Rab7subversion of phosphoinositide metabolismvacuole escapeVps34

Identifiers

PMID36656016
PMCPMC9973280
OpenAlexW4317435874

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.