Evidence map›Paper›PMID 36655996›Full record

ArticleJournal of bacteriology2023

VgrG Spike Dictates PAAR Requirement for the Assembly of the Type VI Secretion System.

Xiaoye Liang, Hao-Yu Zheng, Ya-Jie Zhao, Yi-Qiu Zhang, Tong-Tong Pei, Yang Cui, Ming-Xuan Tang, Ping Xu, Tao Dong

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaoye LiangState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Hao-Yu ZhengState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Ya-Jie ZhaoState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Yi-Qiu ZhangDepartment of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Tong-Tong PeiState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Yang CuiState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Ming-Xuan TangDepartment of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.
Ping XuState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Tao DongDepartment of Immunology and Microbiology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, China.ORCID 0000-0003-3557-1850
Shanghai Jiao Tong University · CNSouthern University of Science and Technology · CN

Funding

MOST | National Key Research and Development Program of China (NKPs) 2018YFA0901200MOST | National Key Research and Development Program of China (NKPs) 2020YFA0907200National Natural Science Foundation of China (NSFC) 32030001
6 · The paper itself

Abstract

Widely employed by Gram-negative pathogens for competition and pathogenesis, the type six protein secretion system (T6SS) can inject toxic effectors into neighboring cells through the penetration of a spear-like structure comprising a long Hcp tube and a VgrG-PAAR spike complex. The cone-shaped PAAR is believed to sharpen the T6SS spear for penetration but it remains unclear why PAAR is required for T6SS functions in some bacteria but dispensable in others. Here, we report the conditional requirement of PAAR for T6SS functions in Aeromonas dhakensis, an emerging human pathogen that may cause severe bacteremia. By deleting the two PAAR paralogs, we show that PAAR is not required for T6SS secretion, bacterial killing, or specific effector delivery in

Indexed as

Type VI Secretion SystemsBacterial ProteinsHumansVirulenceBacterial ProteinsType VI Secretion SystemsAeromonaseffectorinterspecies interactionPAARpathogenesisprotein secretionsecretion systemT6SSVgrGVibrio

Identifiers

PMID36655996
PMCPMC9945574
OpenAlexW4317433326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.