Evidence map›Paper›PMID 36655824›Full record

ReviewLab on a chip2023

Nanoparticle protein corona: from structure and function to therapeutic targeting.

Ghazal Bashiri, Marshall S Padilla, Kelsey L Swingle, Sarah J Shepherd, Michael J Mitchell, Karin Wang

Open access · hybridFull text readReview
In one paragraph

Review in Lab on a chip, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed
22.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 225 citations in OpenAlex.

  1. Review
  2. Toxicity of nanostructures in drug delivery applications.Pharmaceutical science advances · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Linking In Vivo Imaging to Therapeutic Outcome withInternational journal of molecular sciences · 2026
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Bridging solubility, stability, and translation: advances in carbon nanotube-based drug delivery systems.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
    Review
  19. Article
  20. Article

54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ghazal BashiriDepartment of Bioengineering, Temple University, Philadelphia, PA 19122, USA. karin.wang@temple.edu.
Marshall S PadillaDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-3607-790X
Kelsey L SwingleDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8475-9206
Sarah J ShepherdDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Michael J MitchellDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-3628-2244
Karin WangDepartment of Bioengineering, Temple University, Philadelphia, PA 19122, USA. karin.wang@temple.edu.ORCID 0000-0001-7812-2583
University of Pennsylvania · USTemple University · USCalifornia Institute for Regenerative Medicine · US

Funding

In utero gene editing to cure a metabolic liver diseaseR01DK123049 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI PERANTEAU, WILLIAM H. · 2020 to 2024
$3.7M
Targeting stem-like cells and their niche in pancreatic cancerR37CA244911 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Tuomas Tammela · 2020 to 2026
$3.4M
A data-driven drug delivery (4D) platform for probing and treating the chemoresistant bone marrow microenvironmentDP2TR002776 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MITCHELL, MICHAEL J · 2018 to 2018
$2.4M
Modular approach for the delivery of antibodies into the cytoplasm of cellsR01CA241661 · NCI · UNIVERSITY OF PENNSYLVANIA · PI TSOURKAS, ANDREW · 2019 to 2023
$1.8M
Advanced Training at the Interface of Engineering and Oral-Craniofacial SciencesT90DE030854 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI Hyun Koo, Kathleen J Stebe · 2021 to 2026
$1.4M
NCATS NIH HHS DP2 TR002776NCI NIH HHS R01 CA241661NCI NIH HHS R37 CA244911NIDCR NIH HHS T90 DE030854NIDDK NIH HHS R01 DK123049
6 · The paper itself

Abstract

Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine. However, despite the clinical success of NP technology, it is not well-understood how NPs fundamentally change in biological environments. When introduced into physiological fluids, NPs are coated by proteins, forming a protein corona (PC). The PC has the potential to endow NPs with a new identity and alter their bioactivity, stability, and destination. Additionally, the conformation of proteins is sensitive to their physical and chemical surroundings. Therefore, biological factors and protein-NP-interactions can induce changes in the conformation and orientation of proteins

Indexed as

NanoparticlesProtein CoronaBiological FactorsProtein ConformationProteinsBiological FactorsProtein CoronaProteins

Identifiers

PMID36655824
PMCPMC10013352
OpenAlexW4317434639

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read45
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.