Evidence map›Paper›PMID 36655626›Full record

ArticleJournal of veterinary internal medicine2023

Extraesophageal reflux and reflux aspiration in dogs with respiratory diseases and in healthy dogs.

Sirkku Kouki, Sanna J Viitanen, Ninna Koho, Henna P Laurila, Liisa Lilja-Maula, Saila Holopainen, Mikko Neuvonen, Mikko Niemi, Aline Fastrès, Cécile Clercx and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sirkku KoukiDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-5782-5762
Sanna J ViitanenDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-1208-5799
Ninna KohoDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Henna P LaurilaDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Liisa Lilja-MaulaDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Saila HolopainenDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-2448-7672
Mikko NeuvonenDepartment of Clinical Pharmacology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Mikko NiemiDepartment of Clinical Pharmacology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Aline FastrèsDepartment of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.ORCID https://orcid.org/0000-0002-7327-3478
Cécile ClercxDepartment of Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Minna M RajamäkiDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
University of Helsinki · FIUniversity of Liège · BE

Funding

Finnish Foundation of Veterinary ResearchFinnish Kennel ClubFinnish Veterinary Research Foundation
6 · The paper itself

Abstract

backgroundSalivary bile acids are used to diagnose extraesophageal reflux (EER) and to evaluate the risk of reflux aspiration that is associated with respiratory diseases in dogs.

objectivesTo study total bile acid (TBA) concentrations in saliva and in bronchoalveolar lavage fluid (BALF) to investigate EER and reflux aspiration in dogs with respiratory diseases and in healthy dogs. ANIMALS: Thirty-one West Highland White Terriers (WHWTs) with idiopathic pulmonary fibrosis (IPF), 12 dogs with inflammatory airway disease (IAD), 6 dogs with recurrent pneumonia (RP), 26 brachycephalic dogs (BD), 27 healthy WHWTs (HW), 52 healthy dogs (HD). All privately-owned dogs.

methodsSaliva and BALF were collected from dogs in each group.

resultsSalivary TBA concentrations were higher in IPF (median 0.1692 μM, interquartile range [IQR] 0.1115-0.2925 μM, Cohen's d 3.4, 95% confidence interval [CI] 2.2-4.0, P < .001) and BD (0.0256 μM, IQR 0.0086-0.0417 μM, d 0.5, CI -0.1 to 1.1, P = .003) compared to HD (0 μM, IQR not quantifiable [n.q.]-0.0131 μM). Bronchoalveolar lavage fluid TBA concentrations were higher in IPF (0.0117 μM, IQR 0.0048-0.0361 μM, d 0.5, CI 0-1.1, P < .001) compared to HD (0 μM, IQR n.q.-0.0074 μM). CONCLUSION AND CLINICAL IMPORTANCE: Extraesophageal reflux and reflux aspiration occur in healthy dogs and those with respiratory diseases.

Indexed as

Dog DiseasesGastroesophageal RefluxIdiopathic Pulmonary FibrosisRespiratory Tract DiseasesAnimalsBile Acids and SaltsBronchoalveolar Lavage FluidDogsBile Acids and Saltsaerodigestive disorderbile acidcaninecanine idiopathic pulmonary fibrosismass spectrometry

Identifiers

PMID36655626
PMCPMC9889628
OpenAlexW4317475997

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.