Evidence map›Paper›PMID 36655513›Full record

ArticleThe Journal of infectious diseases2023

Vaccine Effectiveness Against 12-Month Incident and Persistent Anal Human Papillomavirus Infection Among Gay, Bisexual, and Other Men Who Have Sex With Men.

Catharine Chambers, Shelley L Deeks, Rinku Sutradhar, Joseph Cox, Alexandra de Pokomandy, Troy Grennan, Trevor A Hart, Gilles Lambert, David M Moore, Daniel Grace and 9 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 1 country.

Catharine ChambersDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-7959-7078
Shelley L DeeksDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Rinku SutradharDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Joseph CoxMcGill University Health Centre - Research Institute, Montréal, Québec, Canada.
Alexandra de PokomandyMcGill University Health Centre - Research Institute, Montréal, Québec, Canada.
Troy GrennanBritish Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
Trevor A HartDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Gilles LambertDirection Régionale de Santé Publique de Montréal, Montréal, Québec, Canada.
David M MooreBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada.
Daniel GraceDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Ramandip GrewalUnity Health Toronto, Toronto, Ontario, Canada.
Jody JollimoreCommunity-Based Research Centre, Vancouver, British Columbia, Canada.
Nathan LachowskySchool of Public Health and Social Policy, University of Victoria, Victoria, British Columbia, Canada.
Rosane NisenbaumDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Gina OgilvieBritish Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
Chantal SauvageauInstitut National de Santé Publique du Québec, Québec, Québec, Canada.
Darrell H S TanUnity Health Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-3069-2875
François CoutléeDépartement de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, Québec, Canada.
Ann N BurchellDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
University of Toronto · CAInstitut National de Santé Publique du Québec · CAMcGill University Health Centre · CAUnity Health TorontoUniversity of British Columbia · CAAIDS Vancouver · CACentre Hospitalier de l’Université de Montréal · CACommunity Based Research Centre · CADalhousie University · CAUniversity of Victoria · CA

Funding

Canadian Institutes for Health Research PJT-153364CIHR 148432CIHR 24103CIHR 415141CIHR FDN-143342CIHR PJT-153139
6 · The paper itself

Abstract

backgroundReal-world evidence of human papillomavirus (HPV) vaccine effectiveness (VE) against longitudinal outcomes is lacking among gay, bisexual, and other men who have sex with men (GBM). We compared 12-month incidence and persistence of anal HPV infection between vaccinated and unvaccinated GBM.

methodsWe recruited GBM aged 16-30 years in Montreal, Toronto, and Vancouver, Canada, from 2017 to 2019. Participants were followed over a median of 12 months (interquartile range, 12-13 months). Participants self-reported HPV vaccination and self-collected anal specimens for HPV DNA testing. We calculated prevalence ratios (PR) for 12-month cumulative incidence and persistence with ≥1 quadrivalent vaccine type (HPV 6/11/16/18) between vaccinated (≥1 dose at baseline) and unvaccinated participants using a propensity score-weighted, modified Poisson regression.

resultsAmong 248 participants, 109 (44.0%) were vaccinated at baseline, of whom 62.6% received 3 doses. PRs for HPV 6/11/16/18 were 0.56 (95% confidence interval [CI], .24-1.31) for cumulative incidence and 0.53 (95% CI, .25-1.14) for persistence. PRs were 0.23 (95% CI, .05-1.03) and 0.08 (95% CI, .01-.59) for incidence and persistence, respectively, among participants who received their first dose at age ≤23 years and 0.15 (95% CI, .03-.68) and 0.12 (95% CI, .03-.54) among participants who were sexually active for ≤5 years before vaccination.

conclusionsFindings support national recommendations for HPV vaccination at younger ages or soon after sexual debut.

Indexed as

Anus DiseasesPapillomavirus InfectionsPapillomavirus VaccinesSexual and Gender MinoritiesVaccine EfficacyAdultCohort StudiesHuman Papillomavirus VirusesHumansIncidenceMaleYoung AdultPapillomavirus Vaccineshuman papillomavirusincidencemen who have sex with menpersistent infectionvaccinationvaccine effectiveness

Identifiers

PMID36655513
PMCPMC10304758
OpenAlexW4317476841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.