ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Association of Subjective and Objective Measures of Sleep With Gut Microbiota Composition and Diversity in Older Men: The Osteoporotic Fractures in Men Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- What is the nature of sleep and circadian rhythm health on gastrointestinal microbiota? A systematic review of studies in humans.Sleep medicine reviews · 2026Pooled it
- The gut microbiome and ageing trajectories: mechanisms and clinical implications.Nature reviews. Endocrinology · 2026Review
- From alpha diversity to zeitgebers: Bacterial gut microbiome associations with sleep and circadian disruption (Part I).Neuroscience and biobehavioral reviews · 2026Review
- The Gut Microbiome in Sleep Disorders: A Review of Recent Evidence.Actas espanolas de psiquiatria · 2026Review
- The interplay of sleep characteristics with health factors and gut microbiome.Nature communications · 2026Article
- Sleep duration associated with altered oral microbiome diversity and composition in the NIH AARP cohort.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Article
- Targeting Cognitive Resilience through Prebiotics: A Focused Perspective.Advances in nutrition (Bethesda, Md.) · 2025Article
- Beyond the Pillow: Linking Subjective and Objective Sleep Measures to Gut Microbiome Composition in Community-Dwelling Older Adults.Nature and science of sleep · 2025Article
- Microbiota-gut-brain axis pathogenesis and targeted therapeutics in sleep disorders.Frontiers in neurology · 2025Review
- Gerontologic Biostatistics and Data Science: Aging Research in the Era of Big Data.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Review
- Gut Bacterial Metabolites from Tryptophan and Phenylalanine Induce Melatonin Synthesis and Extend Sleep Duration in Mice.ACS omega · 2024Article
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10 authors at 9 institutions in 2 countries.
Funding
Abstract
backgroundGrowing evidence suggests bidirectional links between gut microbiota and sleep quality as shared contributors to health. Little is known about the relationship between microbiota and sleep among older persons.
methodsWe used 16S rRNA sequencing to characterize stool microbiota among men (n = 606, mean [standard deviation] age = 83.9 [3.8]) enrolled in the Osteoporotic Fractures in Men (MrOS) study from 2014 to 2016. Sleep was assessed concurrently by a questionnaire (Pittsburgh Sleep Quality index [PSQI]), and activity monitor to examine timing (acrophase) and regularity of patterns (F-statistic). Alpha diversity was measured using Faith's phylogenetic diversity (PD). Beta diversity was calculated with robust Aitchison distance with matrix completion (RPCA) and phylogenetic-RPCA (PRPCA). Their association with sleep variables was tested with partial distance-based redundancy analysis (dbRDA). Predictive-ratio biomarkers associated with sleep measurements were identified with CoDaCoRe.
resultsIn unadjusted analyses, men with poor sleep (PSQI >5) tended to have lower alpha diversity compared to men with normal sleep (Faith's PD, beta = -0.15; 95% confidence interval [CI]: -0.30 to 0.01, p = .06). Sleep regularity was significantly associated with RPCA and PRPCA, even after adjusting for site, batch, age, ethnicity, body mass index, diabetes, antidepressant and sleep medication use, and health behaviors (RPCA/PRPCA dbRDA; p = .033/.002). In taxonomic analysis, ratios of 7:6 bacteria for better regularity (p = .0004) and 4:7 for worse self-reported sleep (p = .005) were differentially abundant: some butyrate-producing bacteria were associated with better sleep characteristics.
conclusionsSubjective and objective indicators of sleep quality suggest that older men with better sleep patterns are more likely to harbor butyrate-producing bacteria associated with better health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.