Evidence map›Paper›PMID 36655309›Full record

ArticlePediatric obesity2023

Neurobehavioral phenotypes of delay discounting and cognitive control in child attention-deficit/hyperactivity disorder and obesity: Shared or distinct?

Gita Thapaliya, Susan Carnell, Stewart H Mostofsky, Keri S Rosch

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Pediatric obesity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04421248 (Anomalous Motor System Physiology in Attention Deficit Hyperactivity Disorder), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04421248 phase4recruitingnot on this map

Anomalous Motor System Physiology in Attention Deficit Hyperactivity Disorder: Biomarker Validation and Modeling Domains of Function

TypeinterventionalSponsorDonald Gilbert, MD, MS, FAAN, FAAPRan2020 to 2026Enrolled214ConditionsAttention Deficit Hyperactivity Disorder CombinedArmsMethylphenidate, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gita ThapaliyaDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-9586-8851
Susan CarnellDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Stewart H MostofskyDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Keri S RoschDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins University · USKennedy Krieger Institute · US

Funding

The Developing Brain: Influences and OutcomesUH3OD023313 · OD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI Viren Andrew D'Sa, Daphne Koinis Mitchell · 2018 to 2026
$20.7M
TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BARKER, PETER B · 2012 to 2020
$13.1M
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Stewart H Mostofsky · 2020 to 2026
$9.9M
Neurology of Deficient Response Control in ADHDR01MH085328 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2009 to 2019
$7.3M
Anomalous Motor Physiology In ADHDR01MH078160 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2006 to 2024
$5.8M
Early Brain Development and Childhood ObesityR01DK113286 · NIDDK · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI CARNELL, SUSAN, D'SA, VIREN ANDREW · 2018 to 2023
$2.5M
Delay Discounting in Children with ADHD: Neuroimaging and Behavioral CorrelatesK23MH101322 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI ROSCH, KERI SHIELS · 2013 to 2017
$735k
Neurobehavioral Correlates of Familial/genetic obesity risk in adolescentsR00DK088360 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CARNELL, SUSAN · 2013 to 2015
$731k
NIBIB NIH HHS P41 EB015909NICHD NIH HHS P50 HD103538NIDDK NIH HHS R00 DK088360NIDDK NIH HHS R01 DK113286NIH HHS K23MH101322NIH HHS P50HD103538NIH HHS R00DK088360NIH HHS R01DK113286NIH HHS R01MH078160NIH HHS R01MH085328NIH HHS UH3 OD023313NIMH NIH HHS K23 MH101322NIMH NIH HHS L40 MH098456NIMH NIH HHS R01 MH078160NIMH NIH HHS R01 MH085328
6 · The paper itself

Abstract

backgroundAttention-deficit/hyperactivity disorder (ADHD) and obesity have been independently associated with deficient cognitive control (CC) and heightened preference for immediate reward.

objectivesWe aimed to identify specific shared and distinct neurobehavioral phenotypes of child obesity and ADHD by simultaneously measuring CC and preference for immediate reward in children with and without ADHD who varied in body weight.

methodsThis case-control study included 323 8-12 year olds (ADHD n = 215, typically developing (TD) screened for ADHD symptoms [TD] controls n = 108) varying in body weight. Children completed a go/no-go task (assessing CC), as well as a classical money delay discounting (DD) task and novel experiential game time DD task (assessing preference for immediate over delayed rewards).

resultsFor game time DD, there was a body mass index z-score (BMIz)*ADHD interaction, such that TD children with overweight/obesity showed game time DD levels that were greater than those of TD children without overweight/obesity and similar to those of children with ADHD. Only children with ADHD showed poorer CC compared to TD children, with no effects of body weight.

conclusionsHeightened game time DD with delays and rewards experienced in real-time may represent a neurobehavioral phenotype that is shared between ADHD and overweight/obesity in childhood, whereas deficient CC may be specific to children with ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityDelay DiscountingPediatric ObesityBody WeightCase-Control StudiesChildCognitionHumansOverweightRewardBMIchildhood obesitycognitive function

Identifiers

PMID36655309
PMCPMC9993809
OpenAlexW4317401504

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.