Evidence map›Paper›PMID 36655171›Full record

ArticleBrain communications2023

Chronic neuronal activation leads to elevated lactate dehydrogenase A through the AMP-activated protein kinase/hypoxia-inducible factor-1α hypoxia pathway.

Alexander Ksendzovsky, Muznabanu Bachani, Marcelle Altshuler, Stuart Walbridge, Armin Mortazavi, Mitchell Moyer, Chixiang Chen, Islam Fayed, Joseph Steiner, Nancy Edwards and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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  10. Hyperpolarized [1-Brain communications · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Alexander KsendzovskyDepartment of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Muznabanu BachaniDrug Development Unit, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.
Marcelle AltshulerSurgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.
Stuart WalbridgeSurgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.
Armin MortazaviSurgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.
Mitchell MoyerDepartment of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Chixiang ChenDepartment of Neurosurgery, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.ORCID https://orcid.org/0000-0001-5474-2833
Islam FayedSurgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0002-4183-4744
Joseph SteinerDepartment of Neurological Surgery, University of Virginia Health System, University of Virginia, Charlottesville, VA 22903, USA.
Nancy EdwardsSurgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.
Sara K InatiOffice of the Clinical Director, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.
Jahandar JahanipourFlow and Cytometry Core, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda MD, 20892, USA.ORCID https://orcid.org/0000-0001-5178-1124
Dragan MaricFlow and Cytometry Core, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda MD, 20892, USA.
John D HeissSurgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.
Jaideep KapurDepartment of Neurology, University of Virginia Health System, University of Virginia, Charlottesville, VA 22903, USA.
Kareem A ZaghloulSurgical Neurology Branch, National Institute of Neurologic Disorders and Stroke, National Institute of Health, Bethesda, MD 20892, USA.ORCID https://orcid.org/0000-0001-8575-3578
National Institute of Neurological Disorders and Stroke · USUniversity of Maryland, Baltimore · USUniversity of Virginia Health System · US

Funding

Investigating the neural mechanisms of human cognitive function through intracranial recordingsZIANS003144 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI ZAGHLOUL, KAREEM · 2014 to 2025
$36.1M
TREATMENT OF STATUS EPILEPTICUSR01NS040337 · NINDS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KAPUR, JAIDEEP · 2000 to 2021
$5.0M
Progress Report for Neurotherapeutics UnitZICNS003149 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NATH, AVINDRA · 2023 to 2025
$4.2M
Flow & Imaging Cytometry Core FacilityZICNS009441 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MARIC, DRAGAN · 2022 to 2025
$3.2M
Motor cortex plasticity in temporal lobe epilepsyR01NS120945 · NINDS · UNIVERSITY OF VIRGINIA · PI KAPUR, JAIDEEP · 2021 to 2025
$2.5M
NINDS NIH HHS R01 NS040337NINDS NIH HHS R01 NS120945
6 · The paper itself

Abstract

Recent studies suggest that changes in neuronal metabolism are associated with epilepsy. High rates of ATP depletion, lactate dehydrogenase A and lactate production have all been found in epilepsy patients, animal and tissue culture models. As such, it can be hypothesized that chronic seizures lead to continuing elevations in neuronal energy demand which may lead to an adapted metabolic response and elevations of lactate dehydrogenase A. In this study, we examine elevations in the lactate dehydrogenase A protein as a long-term cellular adaptation to elevated metabolic demand from chronic neuronal activation. We investigate this cellular adaptation in human tissue samples and explore the mechanisms of lactate dehydrogenase A upregulation using cultured neurones treated with low Mg

Indexed as

epilepsyglycolysisHIF1αLDHAneuronal metabolism

Identifiers

PMID36655171
PMCPMC9838803
OpenAlexW4310437254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.