Evidence map›Paper›PMID 36655124›Full record

ArticleACS medicinal chemistry letters2023

Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors.

Ryjul W Stokes, Alysia J Kohlbrand, Hyeonglim Seo, Banumathi Sankaran, Johannes Karges, Seth M Cohen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ryjul W StokesDepartment of Chemistry and Biochemistry, University of California, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0001-5965-5421
Alysia J KohlbrandDepartment of Chemistry and Biochemistry, University of California, La Jolla, California 92093, United States.
Hyeonglim SeoDepartment of Chemistry and Biochemistry, University of California, La Jolla, California 92093, United States.
Banumathi SankaranThe Berkeley Center for Structural Biology, Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.
Johannes KargesDepartment of Chemistry and Biochemistry, University of California, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0001-5258-0260
Seth M CohenDepartment of Chemistry and Biochemistry, University of California, La Jolla, California 92093, United States.ORCID https://orcid.org/0000-0002-5233-2280
University of California San Diego · USLawrence Berkeley National Laboratory · US

Funding

Metal-binding Isosteres for Influenza Endonuclease Inhibitors and BeyondR01AI149444 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SETH M COHEN · 2020 to 2026
$2.3M
NIAID NIH HHS R01 AI149444
6 · The paper itself

Abstract

Among the most important influenza virus targets is the RNA-dependent RNA polymerase acidic N-terminal (PA

Identifiers

PMID36655124
PMCPMC9841593
OpenAlexW4311141295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.