Evidence map›Paper›PMID 36655039›Full record

ArticlePeerJ2023

Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma.

Karolyny Martins Balbinot, Felippe José Almeida Loureiro, Giordanna Pereira Chemelo, Ricardo Alves Mesquita, Aline Maria Pereira Cruz Ramos, Rommel Thiago Jucá Ramos, Artur Luiz da Costa da Silva, Sílvio Augusto Fernandes de Menezes, Maria Sueli da Silva Kataoka, Sergio de Melo Alves Junior and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Karolyny Martins BalbinotLaboratory of Pathological Anatomy and Immunohistochemistry, Federal University of Pará, Belém, Pará, Brazil.
Felippe José Almeida LoureiroCell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil.
Giordanna Pereira ChemeloCell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil.
Ricardo Alves MesquitaDepartment of Oral Surgery and Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.ORCID 0000-0003-3207-4007
Aline Maria Pereira Cruz RamosHealth Science Institute, Federal University of Pará, Belém, Pará, Brazil.ORCID 0000-0001-8812-2923
Rommel Thiago Jucá RamosBiological Engineer Laboratory, Park of Science and Technology, Belém, Pará, Brazil.ORCID 0000-0002-8032-1474
Artur Luiz da Costa da SilvaBiological Engineer Laboratory, Park of Science and Technology, Belém, Pará, Brazil.ORCID 0000-0002-4082-1132
Sílvio Augusto Fernandes de MenezesDepartment of Periodontics, Pará State University, Belém, Pará, Brazil.
Maria Sueli da Silva KataokaCell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil.
Sergio de Melo Alves JuniorLaboratory of Pathological Anatomy and Immunohistochemistry, Federal University of Pará, Belém, Pará, Brazil.
João de Jesus Viana PinheiroCell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil.ORCID 0000-0002-6914-6441
Universidade Federal do Pará · BRInstituto Federal de Educação, Ciência e Tecnologia do Pará · BRUniversidade do Estado do Pará · BRUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ameloblastoma (AME) is characterized by a locally invasive growth pattern. In an attempt to justify the aggressiveness of neoplasms, the investigation of the role of stem cells has gained prominence. The SOX-2, NANOG and OCT4 proteins are important stem cell biomarkers. Methodology: To verify the expression of these proteins in tissue samples of AME, dentigerous cyst (DC) and dental follicle (DF), immunohistochemistry was performed and indirect immunofluorescence were performed on the human AME (AME-hTERT) cell line. Results: Revealed expression of SOX-2, NANOG and OCT4 in the tissue samples and AME-hTERT lineage. Greater immunostaining of the studied proteins was observed in AME compared to DC and DF ( Conclusions: The presence of biomarkers indicates a probable role of stem cells in the genesis and progression of AME.

Indexed as

AmeloblastomaNeoplastic Stem CellsBiomarkersBiomarkers, TumorCell ProliferationHumansImmunohistochemistryNanog Homeobox ProteinOctamer Transcription Factor-3SOXB1 Transcription FactorsStem CellsBiomarkersBiomarkers, TumorNanog Homeobox ProteinNANOG protein, humanOctamer Transcription Factor-3SOXB1 Transcription FactorsAmeloblastomaImmunohistochemistryOctamer transcription factorsSOX transcription factorsStem cellsTranscriptomic

Identifiers

PMID36655039
PMCPMC9841912
OpenAlexW4316037736

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.