Evidence map›Paper›PMID 36654965›Full record

ArticleMaterials today. Bio2023

Core-shell oxygen-releasing fibers for annulus fibrosus repair in the intervertebral disc of rats.

Yi Zheng, Borui Xue, Bin Wei, Bing Xia, Shengyou Li, Xue Gao, Yiming Hao, Yitao Wei, Lingli Guo, Haining Wu and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 1 country.

Yi ZhengDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Borui XueDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Bin WeiDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Bing XiaDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Shengyou LiDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Xue GaoDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Yiming HaoDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Yitao WeiDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Lingli GuoDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Haining WuDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Yujie YangDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Xueli GaoSchool of Ecology and Environment, Northwestern Polytechnical University, Xi'an, 710072, China.
Beibei YuDepartment of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710004, China.
Yongfeng ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710004, China.
Shijie YangDepartment of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, 710004, China.
Zhuojing LuoDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Teng MaDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Jinghui HuangDepartment of Orthopedics, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
Xijing Hospital · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNNorthwestern Polytechnical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The repair of annulus fibrosus (AF) defect after discectomy in the intervertebral disc (IVD) has presented a challenge over the past decade. Hostile microenvironments in the IVD, including, compression and hypoxia, are critical issues that require special attention. Till date, little information is available on potential strategies to cope with the hypoxia dilemma in AF defect sites. In this study, perfluorotributylamine (PFTBA) core-shell fibers were fabricated by coaxial electrospinning to construct oxygen-releasing scaffold for promoting endogenous repair in the AF after discectomy. We demonstrated that PFTBA fibers (10% chitosan, chitosan: PCL, 1:6) could release oxygen for up to 144 ​h. The oxygen released from PFTBA fibers was found to protect annulus fibrosus stem cells (AFSCs) from hypoxia-induced apoptosis. In addition, the PFTBA fibers were able to promote proliferation, migration and extracellular matrix (ECM) production in AFSCs under hypoxia, highlighting their therapeutic potential in AF defect repair. Subsequent

Indexed as

Annulus fibrosus defectCoaxial electrospinningHypoxiaIntervertebral disc degenerationPerfluorotributylamine

Identifiers

PMID36654965
PMCPMC9841168
OpenAlexW4313529205

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.