Evidence map›Paper›PMID 36654663›Full record

ArticleProceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences2023

Diversity in Digital Pill Systems: Differences in Perceptions and Attitudes Towards Use of a Digital Pill System for HIV Pre-Exposure Prophylaxis Among Men Who Have Sex with Men with Diverse Racial and Ethnic Identities.

Jasper S Lee, Hannah Albrechta, Georgia R Goodman, Dikha De, Koki Takabatake, Conall O'Cleirigh, Kenneth H Mayer, Celia Fisher, Chris T Carnes, Peter R Chai

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the ... Annual Hawaii International Conference on System Sciences. Annual Hawaii International Conference on System Sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
6.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Jasper S LeeDepartment of Psychiatry, Massachusetts General Hospital/Harvard Medical School.
Hannah AlbrechtaThe Fenway Institute, Fenway Health.
Georgia R GoodmanDepartment of Emergency Medicine, Brigham and Women's Hospital.
Dikha DeThe Fenway Institute, Fenway Health.
Koki TakabatakeThe Fenway Institute, Fenway Health.
Conall O'CleirighDepartment of Psychiatry, Massachusetts General Hospital/Harvard Medical School.
Kenneth H MayerThe Fenway Institute, Fenway Health.
Celia FisherCenter for Ethics Education, Fordham University.
Chris T CarnesetectRx.
Peter R ChaiDepartment of Emergency Medicine, Brigham and Women's Hospital.
Fenway Health · USBoston University · USBrigham and Women's Hospital · USDetectogen (United States) · USFordham University · USHadassah Medical Center · ILHarvard University · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ARTHUR Y KIM · 2004 to 2026
$94.4M
Training Program in HIV Prevention Research EthicsR25DA031608 · NIDA · FORDHAM UNIVERSITY · PI FISHER, CELIA B · 2011 to 2025
$4.9M
Smart Steps: A context-aware adherence intervention to improve PrEP adherence among men who have sex with men (MSM) with substance use disorderDP2DA056107 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI CHAI, PETER R · 2022 to 2022
$2.7M
Development of Ingestible Biosensors to Enhance PrEP Adherence in Substance UsersK23DA044874 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI CHAI, PETER R · 2018 to 2022
$1.0M
NIAID NIH HHS P30 AI060354NIDA NIH HHS DP2 DA056107NIDA NIH HHS K23 DA044874NIDA NIH HHS R25 DA031608
6 · The paper itself

Abstract

Nonadherence, particularly among men who have sex with men (MSM) with substance use disorders, increases the risk of HIV acquisition. Measuring adherence to HIV pre-exposure chemoprophylaxis (PrEP), and responding to suboptimal adherence or changes in adherence behavior remains a challenging public health problem. Despite the importance of accurate adherence measurement, there is no gold standard for detecting medication ingestion events in HIV research. Current adherence measures indirectly infer ingestion events or measure medication concentrations over time, yet such approaches fail to provide direct confirmation of ingestions and contextual information surrounding adherence and nonadherence. A digital pill system (DPS) - a novel tool that leverages ingestible radiofrequency sensors to measure actual ingestion events - may advance adherence measurement in HIV research. We examined and compared the willingness of MSM across racial and ethnic identities to operate a DPS in the context of PrEP adherence measurement and suggest potential future applications of this technology.

Indexed as

Digital pill systemsHIV pre-exposure prophylaxisingestible sensorsmedication adherence

Identifiers

PMID36654663
PMCPMC9843706
OpenAlexW4317480511

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.