ArticleEuropean journal of medical research2023
Association between central venous pressure measurement and outcomes in critically ill patients with severe coma.
Article in European journal of medical research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Role of Central Venous Pressure and Mean Arterial Pressure to Central Venous Pressure Ratio in Assessing Poisoning Severity and Poor Outcomes in Intensive Care Unit-Admitted Acute Aluminum Phosphide-Poisoned Patients.Cardiovascular toxicology · 2026Article
- Impact of central venous pressure trajectories on prognosis in ICU patients with sepsis.Scientific reports · 2026Article
- Predictive value of internal jugular vein combining with inferior vena cava diameters by ultrasound in central venous pressure of ICU patients.Scientific reports · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundThe use of central venous pressure (CVP) measurements among (intensive care unit) ICU patients with severe coma has been questioned. This study aimed to investigate the application value of CVP in this population.
methodsData stored in the ICU Collaborative Research Database (eICU-CRD) and Medical Information Mart for Intensive Care III (MIMIC-III) database were reviewed. Critically ill patients with a Glasgow Coma Scale (GCS) score of 3-8 were included. The primary outcome was the in-hospital mortality rate. The statistical approaches used included multivariable Cox regression, propensity score matching (PSM), inverse probability treatment weighting (IPTW), stabilized IPTW, and restricted cubic splines (RCS) to ensure the robustness of our findings.
resultsIn total, 7386 patients were included in the study. Early CVP measurement was independently associated with in-hospital mortality [hazard ratio, 0.63; p < 0.001] in patients with severe-to-moderate coma. This result was robust in the PSM, sIPTW, and IPTW cohorts. For all patients with CVP measurements, the RCS curves showed that the risk of in-hospital mortality increased as the initial CVP time was delayed. In addition, early CVP measurement was significantly associated with lower ICU mortality, 28-day mortality, and 365-day mortality and a significantly higher number of ventilator-free days.
conclusionEarly CVP measurement could improve clinical outcomes in critically ill patients with severe coma.
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