SynthesisReproductive biology and endocrinology : RB&E2023
Lifestyle-, environmental-, and additional health factors associated with an increased sperm DNA fragmentation: a systematic review and meta-analysis.
Synthesis in Reproductive biology and endocrinology : RB&E, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07779954 (Sperm DNA Fragmentation), which is not on this map. Cited by 57 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sperm DNA Fragmentation (SDF) and Infertility in Males - Impact on ART Outcomes and the Efficacy of Lifestyle Interventions
Who cites it
57 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Effect of sperm DNA fragmentation on embryo euploidy rate in assisted reproductive technologies: a systematic review and meta-analysis.European journal of medical research · 2025Pooled it
- Assessing the efficacy of varicocelectomy, antioxidants, FSH treatment, and lifestyle modifications on sperm DNA fragmentation: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Areas of Controversy and Confusion in Male Infertility: A Call for Clarity.The world journal of men's health · 2026Article
- Modifiable key factors and semen quality in men undergoing preconception evaluation: a cross-sectional study.Asian journal of andrology · 2026Article
- Normal spermatogenesis in older men is associated with compensatory transcriptome changes.GeroScience · 2026Article
- What Moves Men to Change? A Mixed-Methods Study on Facilitators and Barriers of Lifestyle Changes in Men Seeking Fertility Care.Andrology · 2026Article
- Trends in Semen Quality: A Contrasting Perspective From a Single-Centre Review in Ireland.Andrology · 2026Article
- Double-stranded sperm DNA fragmentation measured with neutral comet assay as a predictor of IVF outcomes: evidence from three European clinics in a multi-centred prospective study.Human reproduction (Oxford, England) · 2026Article
- Long-Term Epidemiological Trends and Regional Disparities in Male Infertility in Central Asia (1991-2023).International journal of environmental research and public health · 2026Article
- Relationship Between Sperm DNA Fragmentation and Composite Morphological Indices: A Multivariable Analysis.Medicina (Kaunas, Lithuania) · 2026Observational
- Serum IgG1 and IgG3 Antibodies to Chlamydia trachomatis Pgp3 and Hsp60 in Men of Subfertile Couples.The Journal of infectious diseases · 2026Article
- Sperm DNA Fragmentation Is Associated with Impaired Directional Motility and Kinematic Efficiency: A CASA-Based Study.Medicina (Kaunas, Lithuania) · 2026Observational
- Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway.Biomedicines · 2026Review
- Dietary patterns and sperm DNA fragmentation in idiopathic infertile men: A case-control study.Scientific reports · 2026Article
- Diagnostic accuracy of sperm DNA fragmentation index in male infertility: A cohort study.Journal of medical biochemistry · 2026Article
- Comparison of Laparoscopic Varicocelectomy and Microsurgical Varicocelectomy with Internal Spermatic Vein-Superficial Epigastric Vein Bypass in Adolescent Patients.Children (Basel, Switzerland) · 2026Article
- Evaluating Sperm DNA Damage: When and Why It Adds to the Management of the Infertile Man.Advances in experimental medicine and biology · 2026Review
- Advances in immunological research on male infertility.Frontiers in reproductive health · 2026Review
- Seminal dysbiosis in idiopathic male infertility: toward a seminal dysbiosis-inflammatory/oxidative endophenotype-SDF axis.Frontiers in endocrinology · 2026Review
- Male infertility and risk of cardiometabolic conditions: a population-based cohort study.Human reproduction (Oxford, England) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
introductionInfertility affects one in every six couples in developed countries, and approximately 50% is of male origin. In 2021, sperm DNA fragmentation (SDF) testing became an evidence-based test for fertility evaluations depicting fertility more clearly than standard semen parameters. Therefore, we aimed to summarize the potential prognostic factors of a higher SDF.
methodsWe conducted a systematic search in three medical databases and included studies investigating any risk factors for SDF values. We calculated mean differences (MD) in SDF with 95% confidence interval (CI) for exposed and non-exposed individuals.
resultsWe included 190 studies in our analysis. In the group of associated health conditions, varicocele (MD = 13.62%, CI: 9.39-17.84) and impaired glucose tolerance (MD = 13.75%, CI: 6.99-20.51) had the most significant increase in SDF. Among malignancies, testicular tumors had the highest impact, with a maximum of MD = 11.3% (CI: 7.84-14.76). Among infections, the overall effects of both Chlamydia and HPV were negligible. Of lifestyle factors, smoking had the most disruptive effect on SDF - an increase of 9.19% (CI: 4.33-14.06). Different periods of sexual abstinence did not show significant variations in SDF values. Age seemed to have a more drastic effect on SDF from age 50 onwards, with a mean difference of 12.58% (CI: 7.31-17.86). Pollution also had a detrimental effect - 9.68% (CI: 6.85-12.52).
conclusionOf the above risk factors, varicocele, impaired glucose tolerance, testicular tumors, smoking, pollution, and paternal age of over 50 were associated with the highest SDF.
trial registrationCRD42021282533.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.