Evidence map›Paper›PMID 36653584›Full record

ArticleDoklady. Biochemistry and biophysics2023

Interactome of Paraoxonase PON2 Reveals New Pathways for Tumor Growth Regulation.

V D Karlov, N B Pestov, M I Shakhparonov, T V Korneenko

Open access · hybridAbstract read
In one paragraph

Article in Doklady. Biochemistry and biophysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Paraoxonase 2 as a target for aging-related diseases.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

V D KarlovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
N B PestovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
M I ShakhparonovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.
T V KorneenkoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia. tvkorn@gmail.com.
Institute of Bioorganic Chemistry · RURussian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interactome of paraoxonase-2 encoded by the PON2 gene was investigated. A cDNA library was screened using a yeast two-hybrid system to search for new proteins interacting with human PON2. Analysis of the identified candidates, along with previously published data on interactors obtained by other methods, indicates the presence of a significant number of indirect interactions between PON2 and EGFR and, consequently, possible regulation of tumor growth with mutant EGFR involving PON2.

Indexed as

AryldialkylphosphataseNeoplasmsErbB ReceptorsHumansAryldialkylphosphataseErbB ReceptorsPON2 protein, humanACAA2CFAP53/CCDC11DCNinteractomeITM2AparaoxonasePON2PPP4R2SFRP4two-hybrid yeast screening

Identifiers

PMID36653584
PMCPMC9848704
OpenAlexW4317380772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.