Evidence map›Paper›PMID 36653582›Full record

ArticleDoklady. Biochemistry and biophysics2023

Incubation of Lymphocytes with IL-2 Causes the Appearance of Antitumor T Cells Carrying FC, CD25, and LFA-1 on the Surface.

O K Ivanova, T N Sharapova, E A Romanova, D V Yashin, L P Sashchenko

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Article in Doklady. Biochemistry and biophysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

O K IvanovaInstitute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia. olga.k.ivanova@gmail.com.
T N SharapovaInstitute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia.
E A RomanovaInstitute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia.
D V YashinInstitute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia.
L P SashchenkoInstitute of Gene Biology of the Russian Academy of Sciences, Moscow, Russia.
Institute of Gene Biology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To carry out antitumor activity against cells that have lost surface antigens, human lymphocytes must have a certain repertoire of surface proteins capable of contacting a tumor cell and inducing programmed cell death in it. In this work, we showed that activation of healthy donor cells by IL-2 cytokine within 6 days causes the appearance of FasL, CD25, and LFA-1 proteins on CD8+CD25+ T lymphocytes, and also converts the LFA-1 protein into an active form having a high affinity for its target, ICAM-1 integrin. The appearance of these proteins on the surface of this subpopulation of lymphocytes allows them to induce programmed cell death in HLA-negative tumor cells.

Indexed as

Interleukin-2Lymphocyte Function-Associated Antigen-1ApoptosisCD8-Positive T-LymphocytesCytokinesHumansT-LymphocytesCytokinesInterleukin-2Lymphocyte Function-Associated Antigen-1FasLIL-2integrinsTag7tumor cells

Identifiers

PMID36653582
PMCPMC10042969
OpenAlexW4317383015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.