ArticleNature2023
Functional T cells are capable of supernumerary cell division and longevity.
Open access · greenAbstract readComparative Study
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
25.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 156 citations in OpenAlex.
- Pembrolizumab combined with nab-paclitaxel and platinum in recurrent/metastatic HNSCC: efficacy, safety, and survival predictive model.ESMO open · 2026Trial
- Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8Cell · 2024Trial
- LAG3 checkpoint function and its mechanism of action in therapeutic targeting.Nature reviews. Immunology · 2026Review
- Clonal selection of somatic mutations shapes NK cell memory.bioRxiv : the preprint server for biology · 2026Article
- Programmable CAR-engaging particles rewire human CAR T-cell signaling for sustainable ex vivo expansion.Nature communications · 2026Article
- Motherhood's immune legacy reshapes the breast for lasting cancer defence.Immuno-oncology technology · 2026Article
- The TCR in CAR T cell therapy: use it or lose it?Cancer gene therapy · 2026Review
- Rotavirus mucosal immunology: insights and research priorities from an international convening in Liverpool, March 2024.NPJ vaccines · 2026Article
- Oncolytic virotherapy mobilizes tumor-resident, granzyme B-producing bystander CD4Molecular therapy. Oncology · 2026Article
- Immune responses in aging adults.The Journal of clinical investigation · 2026Review
- Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.The Journal of clinical investigation · 2026Article
- HIV-1 Integration Site Determines the Transcriptional Fate and Persistence of Integrated Proviruses.bioRxiv : the preprint server for biology · 2026Article
- Antigen-specific TScience advances · 2026Article
- FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes.The Journal of experimental medicine · 2026Article
- Characteristics and therapeutic resistance mechanisms of the prostate cancer immune microenvironment: a comprehensive analysis from bench to clinic.Frontiers in pharmacology · 2026Review
- The cellular senescence-metabolism axis: emerging insights into T cell dynamics in the context of biological aging.Cell communication and signaling : CCS · 2025Review
- Article
- Stable clonal contribution of lineage-restricted stem cells to human hematopoiesis.Nature genetics · 2025Article
- Ion-interference amplifier nano-system enhances radiotherapy via mitochondrial dysfunction and efferocytosis Inhibition.Journal of nanobiotechnology · 2025Article
- Influence of Electrohydrodynamics (EHD) on the Drying Characteristics and Active Ingredients of Astragalus Membranaceus Slices.Foods (Basel, Switzerland) · 2025Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
11 authors at 5 institutions in 2 countries.
Andrew G SoerensCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-7291-8433
Marco KünzliCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0001-7699-779X
Clare F QuarnstromCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
Milcah C ScottCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-2151-7335
Lee SwansonCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
J J LocquiaoCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
Hazem E GhoneimDepartment of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-9816-4286
Dietmar ZehnDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany.ORCID http://orcid.org/0000-0003-1393-8527
Benjamin YoungbloodDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-1261-9957
Vaiva VezysCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-2520-809X
David MasopustCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA. masopust@umn.edu.ORCID http://orcid.org/0000-0002-9440-3884
University of Minnesota Medical Center · USSt. Jude Children's Research Hospital · USTechnical University of Munich · DEThe Ohio State University · USUniversity of Minnesota · US
Funding
TRAINING-PULMONARY CELL &MOLECULAR BIOLOGY &PHYSIOLOGYT32HL007741 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUDLEY, R. ADAMS, INGBAR, DAVID H · 1994 to 2023
$13.9MMucosal T Cell Memory to PathogensR01AI084913 · NIAID · UNIVERSITY OF MINNESOTA · PI MASOPUST, DAVID · 2010 to 2023
$5.8MResident Memory T CellsR01AI146032 · NIAID · UNIVERSITY OF MINNESOTA · PI DAVID MASOPUST · 2020 to 2026
$3.8MNHLBI NIH HHS T32 HL007741NIAID NIH HHS R01 AI084913NIAID NIH HHS R01 AI146032
Abstract
Differentiated somatic mammalian cells putatively exhibit species-specific division limits that impede cancer but may constrain lifespans
Indexed as
Cell DivisionCellular SenescenceLongevityLymphocyte ActivationT-LymphocytesAdoptive TransferAnimalsCD8-Positive T-LymphocytesCell DifferentiationChronic DiseaseEpigenesis, GeneticImmunization, SecondaryImmunologic MemoryInfectionsMiceNeoplasmsPdcd1 protein, mouseProgrammed Cell Death 1 Receptor
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.