ArticleScientific reports2023
Functions of human olfactory mucus and age-dependent changes.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- On or within: spatial determinants of antigen handling in the nasal turbinates.Current opinion in immunology · 2026Review
- Cell-type Plasticity Supports Behavioral Adaptations at the Water-to-Land Interface.bioRxiv : the preprint server for biology · 2026Article
- Rapid odorant metabolism organizes identity- and timing-based odor representations by olfactory bulb inputs and outputs.bioRxiv : the preprint server for biology · 2026Article
- D-alanine aminotransferase (Dat) promotesbioRxiv : the preprint server for biology · 2026Article
- Optimizing Odorants for Olfactory Training Based on Olfactory Receptor-Ligand Pair Analysis.The Laryngoscope · 2026Article
- Intranasal pH and Olfactory Function Among Healthy Adults.The Laryngoscope · 2025Article
- Kinetic selectivity in metal-organic framework chemical sensors.Nature communications · 2025Article
- An odorant receptor for a key odor constituent of ambergris.Communications biology · 2025Article
- Fibronectin in the olfactory mucus increases sensitivity of olfactory receptor response to odorants.Science advances · 2025Article
- The influence of Black Cohosh on hippocampal and hypothalamic gene expression profiles in ovariectomized rats and its potential to treat menopausal decrease in smell discrimination.Archives of gynecology and obstetrics · 2024Article
- Article
- Olfactory immunology: the missing piece in airway and CNS defence.Nature reviews. Immunology · 2024Review
- Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals.Beilstein journal of nanotechnology · 2024Review
- The Latest Cellular and Molecular Mechanisms of COVID-19 on Non-Lung Organs.Brain sciences · 2023Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Odorants are detected by olfactory sensory neurons, which are covered by olfactory mucus. Despite the existence of studies on olfactory mucus, its constituents, functions, and interindividual variability remain poorly understood. Here, we describe a human study that combined the collection of olfactory mucus and olfactory psychophysical tests. Our analyses revealed that olfactory mucus contains high concentrations of solutes, such as total proteins, inorganic elements, and molecules for xenobiotic metabolism. The high concentrations result in a capacity to capture or metabolize a specific repertoire of odorants. We provide evidence that odorant metabolism modifies our sense of smell. Finally, the amount of olfactory mucus decreases in an age-dependent manner. A follow-up experiment recapitulated the importance of the amount of mucus in the sensitive detection of odorants by their receptors. These findings provide a comprehensive picture of the molecular processes in olfactory mucus and propose a potential cause of olfactory decline.
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