Evidence map›Paper›PMID 36653193›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

α-Synuclein Promotes Neuronal Dysfunction and Death by Disrupting the Binding of Ankyrin to β-Spectrin.

Gali Maor, Ronald R Dubreuil, Mel B Feany

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. The Role and Mechanisms of G protein-coupled receptors in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
  5. Review
  6. Article
  7. Biochemical Fractionation of Human α-Synuclein in aInternational journal of molecular sciences · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Alpha Synuclein: Neurodegeneration and Inflammation.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Gali MaorDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Ronald R DubreuilDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607.
Mel B FeanyDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115 mel_feany@hms.harvard.edu.
Brigham and Women's Hospital · USHarvard University · USUniversity of Illinois Chicago · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Genome Wide Analysis of Alpha-Synuclein NeurotoxicityR01NS098821 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI FEANY, MEL B · 2017 to 2021
$3.1M
NIH HHS P40 OD018537NINDS NIH HHS R01 NS098821
6 · The paper itself

Abstract

α-Synuclein plays a key role in the pathogenesis of Parkinson's disease and related disorders, but critical interacting partners and molecular mechanisms mediating neurotoxicity are incompletely understood. We show that α-synuclein binds directly to β-spectrin. Using males and females in a

Indexed as

Parkinson DiseaseSpectrinAdenosine Triphosphatasesalpha-SynucleinAnimalsAnkyrinsDrosophilaFemaleHumansMaleMembrane ProteinsNeuronsAdenosine Triphosphatasesalpha-SynucleinAnkyrinsMembrane ProteinsSNCA protein, humanSpectrinDrosophilaParkinson’s diseasespectrinα-synuclein

Identifiers

PMID36653193
PMCPMC10008058
OpenAlexW4317384288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.