ArticleNeurology2023
Age-Related Differences in the Role of Risk Factors for Ischemic Stroke.
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of Early Risk Factors Associated with Cerebrovascular Diseases.Current neurovascular research · 2026Pooled it
- Late-Life Incident Stroke in the Atherosclerosis Risk in Communities Study: Etiology and Prediction.Stroke · 2026Article
- Age-Dependent Association between Heart Failure and Stroke Risk in Atrial Fibrillation: A Nationwide Cohort Study.Journal of the American Heart Association · 2026Article
- Cardiovascular Events in US Adults Aged ≥80 Years: Incidence, Risk Factors, and Outcomes.Circulation. Population health and outcomes · 2026Article
- The role of biological age in stroke prediction: evidence from CHARLS and machine learning models.BMC neurology · 2026Article
- Association of FLAIR Positivity and Worse Outcomes After Intravenous Thrombolysis in Known-Onset Strokes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Cardiovascular Risk Prediction in Older Adults.Current atherosclerosis reports · 2025Review
- Poor Olfaction and Risk of Stroke in Older Adults: The Atherosclerosis Risk in Communities Study.Stroke · 2025Article
- Predicting new-onset stroke with machine learning: development of a model integrating traditional Chinese and western medicine.Frontiers in pharmacology · 2025Article
- Association between stroke and memory diseases: evidence from a prospective national cohort study in China.Frontiers in neurology · 2025Article
- Prevalence of stroke in young adults in the Middle East and North Africa Region: A systematic review and meta-analysis.PLOS global public health · 2025Article
- Clinical effects of acupuncture treatment for prevention of insomnia-induced stroke: A large-scale cohort study.Journal of traditional and complementary medicine · 2025Article
- Association of triglyceride glucose index with clinical outcomes in ischemic stroke: a retrospective study.BMC neurology · 2024Observational
- Article
- Race-ethnicity, age, and heart failure in ischemic stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Article
- Olfactory Impairment and the Risk of Major Adverse Cardiovascular Outcomes in Older Adults.Journal of the American Heart Association · 2024Article
- Exploring Stroke Risk through Mendelian Randomization: A Comprehensive Study Integrating Genetics and Metabolic Traits in the Korean Population.Biomedicines · 2024Article
- SRPNet: stroke risk prediction based on two-level feature selection and deep fusion network.Frontiers in physiology · 2024Article
- Age-Related Differences in the Contribution of Systolic Blood Pressure and Biomarkers to Cardiovascular Disease Risk Prediction: The Atherosclerosis Risk in Communities (ARIC) Study.The American journal of cardiology · 2023Article
- Identifying risk factors and predicting stroke using Bayesian networks: Evidence from NHANES 2011-2020.Digital healthArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
objectivesReports assessing the association of stroke risk factors with incident stroke have generally assumed a uniform magnitude of associations across the age spectrum, an assumption we assess in this report.
methodsParticipants enrolled 2003-2007 in the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort study who were stroke free at baseline were followed for incident stroke. Associations of traditional stroke risk factors with incident stroke were assessed using (1) proportional hazards analysis based on the baseline age of the participant and (2) Poisson regression analysis assessing associations based on the changing age of the participant during their follow-up (age at exposure). In each analysis, age strata were selected to have a similar number of strokes in each stratum, specifically 45-64, 65-73, and 74+ years for the proportional hazards analysis and 45-69, 70-79, and 80+ years for Poisson regression.
resultsA total of 1,405 ischemic stroke events occurred among 28,235 participants over a median follow-up of 11.3 years, with a total of 276,074 person-years exposure. For both analytic approaches, the magnitude of the association with stroke was significantly less at older ages for diabetes (hazard or relative risk decreasing from ≈2.0 in younger strata to ≈1.3 in older strata), heart disease (from ≈2.0 to ≈1.3), and hypertension defined at a threshold of 140/90 mm Hg (from ≈1.80 to ≈1.50); however, there was no age-related difference in the magnitude of the association for smoking, atrial fibrillation, or left ventricular hypertrophy. DISCUSSION: Hypertension and diabetes are 2 of the more important risk factors for stroke; however, their association with stroke risk appears substantially less at older ages. That the magnitude of the association for smoking, atrial fibrillation, and left ventricular hypertrophy does not decrease with age suggests their relative importance in determining stroke risk likely increases with age.
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