Evidence map›Paper›PMID 36652919›Full record

ArticleCell reports. Medicine2023

Successful restoration of spermatogenesis following gender-affirming hormone therapy in transgender women.

Iris de Nie, Norah M van Mello, Emanuel Vlahakis, Charlie Cooper, Angus Peri, Martin den Heijer, Andreas Meißner, Judith Huirne, Ken C Pang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  7. A new humanHuman reproduction open · 2025
    Article
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  11. Review
  12. Article
  13. Article
  14. Fertility counseling guide for transgender and gender diverse people.International journal of transgender health · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Iris de NieDepartment of Endocrinology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands; Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
Norah M van MelloCenter of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands; Department of Obstetrics and Gynecology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
Emanuel VlahakisCoffs Harbour Sexual Health Clinic, Coffs Harbour, NSW, Australia.
Charlie CooperClinical Sciences, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Adolescent Medicine, Royal Children's Hospital, Melbourne, VIC, Australia.
Angus PeriClinical Sciences, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Adolescent Medicine, Royal Children's Hospital, Melbourne, VIC, Australia.
Martin den HeijerDepartment of Endocrinology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands; Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
Andreas MeißnerDepartment of Endocrinology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands; Center of Expertise on Gender Dysphoria, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands; Department of Urology, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.
Judith HuirneDepartment of Obstetrics and Gynecology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, the Netherlands.
Ken C PangClinical Sciences, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of Adolescent Medicine, Royal Children's Hospital, Melbourne, VIC, Australia; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. Electronic address: ken.pang@mcri.edu.au.
Amsterdam University Medical Centers · NLRoyal Children's Hospital · AUCoffs Harbour City Council · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing numbers of transgender individuals are presenting for gender-affirming medical care. For trans women, gender-affirming hormone therapy (GAHT) promotes feminization but also inhibits spermatogenesis. There is a common untested assumption that this inhibition is permanent, resulting in infertility. In this longitudinal study, we report the recovery of viable spermatozoa in nine trans women who stopped GAHT for reproductive purposes. Our preliminary findings suggest that the negative impact of GAHT on spermatogenesis can be reversed, casting doubt on previous claims that GAHT in trans women inevitably leads to permanent infertility. Larger studies are needed to confirm our findings, which have implications not only for fertility counseling and the reproductive options of transgender individuals but also efforts to restrict access to GAHT based on fertility grounds.

Indexed as

InfertilityTransgender PersonsFemaleHormonesHumansLongitudinal StudiesMaleSpermatogenesisHormonesanti-androgensazoospermiaestrogenfertilitygender-affirming hormonesspermatogenesistransgender

Identifiers

PMID36652919
PMCPMC9873819
OpenAlexW4317033456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.