Evidence map›Paper›PMID 36652561›Full record

ReviewMolecular pharmaceutics2023

Calcium Phosphate Delivery Systems for Regeneration and Biomineralization of Mineralized Tissues of the Craniofacial Complex.

Darnell L Cuylear, Nafisa A Elghazali, Sunil D Kapila, Tejal A Desai

Open access · hybridAbstract readReview
In one paragraph

Review in Molecular pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Darnell L CuylearGraduate Program in Oral and Craniofacial Sciences, School of Dentistry, University of California, San Francisco, California 94143-2520, United States.ORCID 0000-0002-8120-4501
Nafisa A ElghazaliDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94143-2520, United States.
Sunil D KapilaSection of Orthodontics, School of Dentistry, University of California, Los Angeles, California 90095-1668, United States.
Tejal A DesaiGraduate Program in Oral and Craniofacial Sciences, School of Dentistry, University of California, San Francisco, California 94143-2520, United States.ORCID 0000-0003-3409-9208
University of California, San Francisco · USUniversity of California, Los Angeles · US

Funding

Therapeutic Application of Painless Nerve Growth Factor to Accelerate Endochondral Fracture RepairR01AR077761 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BAHNEY, CHELSEA SHIELDS · 2021 to 2025
$3.2M
Local Sustained Delivery of Osteoprotegerin via Hydroxyapatite Microparticles to Enhance Post-Orthodontic Tooth StabilityF30DE031158 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Darnell Cuylear · 2021 to 2026
$308k
NIAMS NIH HHS R01 AR077761NIDCR NIH HHS F30 DE031158
6 · The paper itself

Abstract

Calcium phosphate (CaP)-based materials have been extensively used for mineralized tissues in the craniofacial complex. Owing to their excellent biocompatibility, biodegradability, and inherent osteoconductive nature, their use as delivery systems for drugs and bioactive factors has several advantages. Of the three mineralized tissues in the craniofacial complex (bone, dentin, and enamel), only bone and dentin have some regenerative properties that can diminish due to disease and severe injuries. Therefore, targeting these regenerative tissues with CaP delivery systems carrying relevant drugs, morphogenic factors, and ions is imperative to improve tissue health in the mineralized tissue engineering field. In this review, the use of CaP-based microparticles, nanoparticles, and polymer-induced liquid precursor (PILPs) amorphous CaP nanodroplets for delivery to craniofacial bone and dentin are discussed. The use of these various form factors to obtain either a high local concentration of cargo at the macroscale and/or to deliver cargos precisely to nanoscale structures is also described. Finally, perspectives on the field using these CaP materials and next steps for the future delivery to the craniofacial complex are presented.

Indexed as

BiomineralizationCollagenBone and BonesCalcium PhosphatesTissue EngineeringCalcium PhosphatesCollagenbiomineralizationcalcium phosphatescraniofacial bone defectsdental decaydentindrug deliveryintrafibrillar mineralization

Identifiers

PMID36652561
PMCPMC9906782
OpenAlexW4317254604

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.