Evidence map›Paper›PMID 36652536›Full record

ReviewScience translational medicine2023

Allergy: Mechanistic insights into new methods of prevention and therapy.

Cezmi A Akdis, Mübeccel Akdis, Scott D Boyd, Vanitha Sampath, Stephen J Galli, Kari C Nadeau

Abstract readReview
In one paragraph

Review in Science translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Establishment of HAnalytical and bioanalytical chemistry · 2026
    Article
  2. Review
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  6. Effects of pre- and postnatal probiotic and ω-3 fatty acid supplementation on cytokine and chemokine responses to allergens and TLR ligands during infancy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
  7. Article
  8. Article
  9. Review
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  11. Article
  12. Article
  13. Review
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  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cezmi A AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos CH-7265, Switzerland.ORCID 0000-0001-8020-019X
Mübeccel AkdisSwiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos CH-7265, Switzerland.ORCID 0000-0003-0554-9943
Scott D BoydSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-0963-044X
Vanitha SampathSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-9639-5024
Stephen J GalliSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-5736-5340
Kari C NadeauSean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-2146-2955

Funding

Tracking allergen specific T cells in multi-food allergyU19AI104209 · NIAID · STANFORD UNIVERSITY · PI GALLI, STEPHEN JOSEPH · 2013 to 2025
$17.3M
SEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrierU01AI147462 · NIAID · STANFORD UNIVERSITY · PI Mary Johnson, GIDEON LACK · 2020 to 2026
$14.0M
T Cell Reagent Research for Monitoring T Cell in Food AllergyU01AI140498 · NIAID · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2018 to 2022
$1.8M
Effects of IgE Blockade on T Cells in Food AllergyR01AI140134 · NIAID · STANFORD UNIVERSITY · PI NADEAU, KARI C. · 2018 to 2021
$1.6M
NIAID NIH HHS R01 AI140134NIAID NIH HHS U01 AI140498NIAID NIH HHS U01 AI147462NIAID NIH HHS U19 AI104209
6 · The paper itself

Abstract

In the past few decades, the prevalence of allergic diseases has increased worldwide. Here, we review the etiology and pathophysiology of allergic diseases, including the role of the epithelial barrier, the immune system, climate change, and pollutants. Our current understanding of the roles of early life and infancy; diverse diet; skin, respiratory, and gut barriers; and microbiome in building immune tolerance to common environmental allergens has led to changes in prevention guidelines. Recent developments on the mechanisms involved in allergic diseases have been translated to effective treatments, particularly in the past 5 years, with additional treatments now in advanced clinical trials.

Indexed as

Food HypersensitivityHypersensitivityAllergensDietHumansSkinAllergens

Identifiers

PMID36652536
PMCPMC12998978

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.