Evidence map›Paper›PMID 36652524›Full record

ArticleScience advances2023

Robust dynamic brain coactivation states estimated in individuals.

Xiaolong Peng, Qi Liu, Catherine S Hubbard, Danhong Wang, Wenzhen Zhu, Michael D Fox, Hesheng Liu

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 54 citations in OpenAlex.

  1. Trial
  2. Sharp and smooth state transitions during resting state brain dynamics.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. The promise of precision functional mapping for neuroimaging in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  14. Article
  15. Brain network dynamics in patients with single- and multiple-domain amnestic mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Xiaolong PengDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-4488-9628
Qi LiuChangping Laboratory, Beijing, China.ORCID 0000-0003-4008-2226
Catherine S HubbardDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.
Danhong WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Wenzhen ZhuDepartment of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Michael D FoxCenter for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0001-8848-6399
Hesheng LiuDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID 0000-0002-7233-1509
Medical University of South Carolina · USAthinoula A. Martinos Center for Biomedical Imaging · USBrigham and Women's Hospital · USTongji Hospital · CN

Funding

The neural network of OCD, linking NHP and human studiesP50MH106435 · NIMH · UNIVERSITY OF ROCHESTER · PI Mary Louise Phillips · 2015 to 2026
$28.9M
Mapping the intrinsic functional organization of auditory cortex in individual subjects using 7T MRIR01DC017991 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI AHVENINEN, JYRKI · 2019 to 2023
$4.0M
Individually targeted neuromodulation for contamination-based OCDR61MH121640 · NIMH · MCLEAN HOSPITAL · PI BRENNAN, BRIAN P. · 2021 to 2022
$2.1M
Understanding Functional Connectivity Abnormalities In Individual Patients with PsychosisK01MH111802 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, DANHONG · 2017 to 2021
$931k
DYT1 Genotype- and Phenotype-Specific Brain Circuits in DystoniaR21NS120186 · NINDS · MGH INSTITUTE OF HEALTH PROFESSIONS · PI KIMBERLEY, TERESA JACOBSON, LIU, HESHENG · 2021 to 2021
$465k
NIDCD NIH HHS R01 DC017991NIMH NIH HHS K01 MH111802NIMH NIH HHS P50 MH106435NIMH NIH HHS R61 MH121640NINDS NIH HHS R21 NS120186
6 · The paper itself

Abstract

A confluence of evidence indicates that brain functional connectivity is not static but rather dynamic. Capturing transient network interactions in the individual brain requires a technology that offers sufficient within-subject reliability. Here, we introduce an individualized network-based dynamic analysis technique and demonstrate that it is reliable in detecting subject-specific brain states during both resting state and a cognitively challenging language task. We evaluate the extent to which brain states show hemispheric asymmetries and how various phenotypic factors such as handedness and gender might influence network dynamics, discovering a right-lateralized brain state that occurred more frequently in men than in women and more frequently in right-handed versus left-handed individuals. Longitudinal brain state changes were also shown in 42 patients with subcortical stroke over 6 months. Our approach could quantify subject-specific dynamic brain states and has potential for use in both basic and clinical neuroscience research.

Identifiers

PMID36652524
PMCPMC9848428
OpenAlexW4317254652

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.