ArticleScience advances2023
Disynaptic specificity of serial information flow for conditioned fear.
Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- The representational geometry of emotional states in basolateral amygdala.Nature neuroscience · 2026Article
- Corticotropin-Releasing Factor and Somatostatin Neurons in the Central Amygdala Mediate Dynamic Defensive Behaviors during Fear Extinction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Morphological and electrophysiological diversity and connectivity of principal neurons in the lateral and basal nuclei of the mouse amygdala.Scientific reports · 2025Article
- Article
- Neural mechanisms underlying strain preference behaviour and plasticity in mice.Scientific reports · 2025Article
- Persistent Threat Avoidance Following Negative Reinforcement Is Not Associated with Elevated State Anxiety.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- PTEN in somatostatin neurons regulates fear and anxiety and is required for inhibitory synaptic connectivity within central amygdala.Frontiers in cellular neuroscience · 2025Article
- Bidirectional valence coding in amygdala intercalated clusters: A neural substrate for the opponent-process theory of motivation.Neuroscience research · 2024Article
- Distributed circuits regulating defensive state transitions: freezing, flight and fight.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Impaired oxytocin signalling in the central amygdala in rats with chronic heart failure.The Journal of physiology · 2024Article
- Activation of NPY Receptors in the BLA Inhibits Projections to the Bed Nucleus of the Stria Terminalis and Buffers Stress-Induced Decreases in Social Interaction in Male Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Prefrontal Dopamine in Flexible Adaptation to Environmental Changes: A Game for Two Players.Biomedicines · 2023Review
- Pavlovian Fear Conditioning Is More than You Think It Is.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Impaired oxytocin signaling in the central amygdala in rats with chronic heart failure.bioRxiv : the preprint server for biology · 2023Article
- From aversive associations to defensive programs: experience-dependent synaptic modifications in the central amygdala.Trends in neurosciences · 2023Review
- Cerebellar control of fear learning via the cerebellar nuclei-Multiple pathways, multiple mechanisms?Frontiers in systems neuroscience · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory encoding and retrieval rely on specific interactions across multiple brain areas. Although connections between individual brain areas have been extensively studied, the anatomical and functional specificity of neuronal circuit organization underlying information transfer across multiple brain areas remains unclear. Here, we combine transsynaptic viral tracing, optogenetic manipulations, and calcium dynamics recordings to dissect the multisynaptic functional connectivity of the amygdala. We identify a distinct basolateral amygdala (BLA) subpopulation that connects disynaptically to the periaqueductal gray (PAG) via the central amygdala (CeA). This disynaptic pathway serves as a core circuit element necessary for the learning and expression of conditioned fear and exhibits learning-related plasticity. Together, our findings demonstrate the utility of multisynaptic approaches for functional circuit analysis and indicate that disynaptic specificity may be a general feature of neuronal circuit organization.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.