Evidence map›Paper›PMID 36652483›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Genome editing in plants using the compact editor CasΦ.

Zheng Li, Zhenhui Zhong, Zhongshou Wu, Patrick Pausch, Basem Al-Shayeb, Jasmine Amerasekera, Jennifer A Doudna, Steven E Jacobsen

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Wheat's Up with CRISPR-Cas-Current Advances, Obstacles and Perspectives.International journal of molecular sciences · 2026
    Review
  3. Virus-induced transgene- and tissue culture-free heritable genome editing in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. CRISPR-Cas applications in agriculture and plant research.Nature reviews. Molecular cell biology · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Zheng LiDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Zhenhui ZhongDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.ORCID 0000-0002-8438-0375
Zhongshou WuDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Patrick PauschLife Sciences Center - European Molecular Biology Laboratory (LSC-EMBL) Partnership for Genome Editing Technologies, Vilnius University - Life Sciences Center, Vilnius 10257, Lithuania.
Basem Al-ShayebInnovative Genomics Institute, University of California, Berkeley, CA 94720.
Jasmine AmerasekeraDepartment of Human Genetics, University of California, Los Angeles, CA 90095.
Jennifer A DoudnaInnovative Genomics Institute, University of California, Berkeley, CA 94720.ORCID 0000-0001-9161-999X
Steven E JacobsenDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
University of California, Los Angeles · USInnovative Genomics Institute · USQB3 · USVilnius University · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) systems have been developed as important tools for plant genome engineering. Here, we demonstrate that the hypercompact CasΦ nuclease is able to generate stably inherited gene edits in

Indexed as

ArabidopsisArabidopsis ProteinsCRISPR-Cas SystemsGene EditingGenome, PlantHomeodomain ProteinsPlantsTranscription FactorsArabidopsis ProteinsFWA protein, ArabidopsisHomeodomain ProteinsTranscription FactorsCasΦ variantsCRISPR-CasΦDNA methylationoff-target editingplant genome editing

Identifiers

PMID36652483
PMCPMC9942878
OpenAlexW4317359003

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.