Evidence map›Paper›PMID 36652477›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Distinct and opposite effects of leukemogenic

Jerome Fortin, Ming-Feng Chiang, Cem Meydan, Jonathan Foox, Parameswaran Ramachandran, Julie Leca, François Lemonnier, Wanda Y Li, Miki S Gams, Takashi Sakamoto and 13 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. MutantProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Epigenetics-targeted drugs: current paradigms and future challenges.Signal transduction and targeted therapy · 2024
    Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Distinct and opposite effects of leukemogenicProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 5 countries.

Jerome FortinPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Ming-Feng ChiangPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Cem MeydanDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.
Jonathan FooxDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.
Parameswaran RamachandranPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Julie LecaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
François LemonnierPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Wanda Y LiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Miki S GamsDepartment of Immunology, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-7485-6595
Takashi SakamotoPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Mandy ChuPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Chantal TobinPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Eric LaugesenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Troy M RobinsonHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Annick You-TenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Daniel J ButlerDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.
Thorsten BergerPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Mark D MindenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Ross L LevineHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Cynthia J GuidosDepartment of Immunology, The Hospital for Sick Children Research Institute, University of Toronto, Toronto, ON M5G 0A4, Canada.
Ari M MelnickDepartment of Medicine, Division of Hematology and Medical Oncology, Weill Cornell Medicine, New York, NY 10021.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065.ORCID 0000-0002-1850-1642
Tak W MakPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.ORCID 0000-0001-6766-861X
University Health Network · CACornell University · USMemorial Sloan Kettering Cancer Center · USUniversity of Toronto · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Mutations in

Indexed as

DioxygenasesDNA-Binding ProteinsIsocitrate DehydrogenaseStem CellsAnimalsKetoglutaric AcidsMiceMutationNeoplasmsDioxygenasesDNA-Binding ProteinsIsocitrate DehydrogenaseKetoglutaric AcidsTet2 protein, mouseepigeneticsIDHmyeloid neoplasmTET2

Identifiers

PMID36652477
PMCPMC9942850
OpenAlexW4317359908

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.