Evidence map›Paper›PMID 36652438›Full record

ArticleAutophagy2023

Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes.

Nivedita Hegdekar, Chinmoy Sarkar, Sabrina Bustos, Rodney M Ritzel, Marie Hanscom, Prarthana Ravishankar, Deepika Philkana, Junfang Wu, David J Loane, Marta M Lipinski

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Review
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  8. [Mechanisms of Piezo1-mediated microglial ferroptosis in inhibiting spinal cord injury repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
  9. Study on the Effects and Mechanisms of Resveratrol in Improving Cognitive Impairment in AβJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
    Article
  10. Review
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  18. Characterization ofMicroorganisms · 2026
    Article
  19. Rubicon modulates neuroimmune responses following traumatic brain injury.bioRxiv : the preprint server for biology · 2026
    Article
  20. Article

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Nivedita HegdekarDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Chinmoy SarkarDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Sabrina BustosDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Rodney M RitzelDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Marie HanscomDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Prarthana RavishankarDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Deepika PhilkanaDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Junfang WuDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
David J LoaneDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
Marta M LipinskiDepartment of Anesthesiology and Shock, Trauma and Anesthesiology Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-7537-9014
University of Maryland, Baltimore · US

Funding

The new roles of the autophagy-lysosomal pathway in spinal cord injury-mediated dementiaR01NS094527 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI MARTA M LIPINSKI, Junfang Wu · 2016 to 2026
$3.5M
Dysregulation of autophagy-lysosomal function links TBI to late-onset neurodegenerationR01NS115876 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIPINSKI, MARTA M · 2020 to 2024
$3.1M
Function and Mechanisms of Autophagy-Lysosomal Pathway in Traumatic Brain InjuryR01NS091218 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LIPINSKI, MARTA M · 2015 to 2019
$1.8M
NINDS NIH HHS R01 NS091218NINDS NIH HHS R01 NS094527NINDS NIH HHS R01 NS115876
6 · The paper itself

Abstract

Excessive and prolonged neuroinflammation following traumatic brain injury (TBI) contributes to long-term tissue damage and poor functional outcomes. However, the mechanisms contributing to exacerbated inflammatory responses after brain injury remain poorly understood. Our previous work showed that macroautophagy/autophagy flux is inhibited in neurons following TBI in mice and contributes to neuronal cell death. In the present study, we demonstrate that autophagy is also inhibited in activated microglia and infiltrating macrophages, and that this potentiates injury-induced neuroinflammatory responses. Macrophage/microglia-specific knockout of the essential autophagy gene

Indexed as

Brain Injuries, TraumaticMicrogliaAnimalsAutophagyImmunity, InnateInflammasomesInflammationMacrophagesMiceMice, Inbred C57BLNeuroinflammatory DiseasesNLR Family, Pyrin Domain-Containing 3 ProteinInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinAutophagyinnate immunitymacrophagemicroglianeuroinflammationtraumatic brain injury

Identifiers

PMID36652438
PMCPMC10283445
OpenAlexW4317358924

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.