Evidence map›Paper›PMID 36652289›Full record

ArticleeLife2023

Differential processing of decision information in subregions of rodent medial prefrontal cortex.

Geoffrey W Diehl, A David Redish

Abstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Geoffrey W DiehlDepartment of Neuroscience, University of Minnesota, Minneapolis, United States.
A David RedishDepartment of Neuroscience, University of Minnesota, Minneapolis, United States.ORCID 0000-0003-3644-9072

Funding

Testing hybrid theories of action-selectionR01MH112688 · NIMH · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH · 2017 to 2026
$5.0M
Using Computation to Achieve Breakthroughs in NeuroscienceT32MH115886 · NIMH · UNIVERSITY OF MINNESOTA · PI REDISH, A DAVID · 2018 to 2022
$1.7M
NIMH NIH HHS R01 MH112688NIMH NIH HHS T32 MH115886
6 · The paper itself

Abstract

Decision-making involves multiple cognitive processes requiring different aspects of information about the situation at hand. The rodent medial prefrontal cortex (mPFC) has been hypothesized to be central to these abilities. Functional studies have sought to link specific processes to specific anatomical subregions, but past studies of mPFC have yielded controversial results, leaving the precise nature of mPFC function unclear. To settle this debate, we recorded from the full dorso-ventral extent of mPFC in each of 8 rats, as they performed a complex economic decision task. These data revealed four distinct functional domains within mPFC that closely mirrored anatomically identified subregions, including novel evidence to divide prelimbic cortex into dorsal and ventral components. We found that dorsal aspects of mPFC (ACC, dPL) were more involved in processing information about active decisions, while ventral aspects (vPL, IL) were more engaged in motivational factors.

Indexed as

Prefrontal CortexRodentiaAnimalsRatsanterior cingulate cortexdecision makinginfralimbic cortexneuroeconomicsneuroscienceprefrontal cortexprelimbic cortexrat

Identifiers

PMID36652289
PMCPMC9848391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.