Evidence map›Paper›PMID 36652206›Full record

ArticleChemical research in toxicology2023

Nature-Derived Epoxy Resin Monomers with Reduced Sensitizing Capacity─Isosorbide-Based Bis-Epoxides.

Isabella Karlsson, David J Ponting, Miguel A Ortega, Ida B Niklasson, Lorena Ndreu, E Johanna L Stéen, Tina Seifert, Kristina Luthman, Ann-Therese Karlberg

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In one paragraph

Article in Chemical research in toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Challenges in diagnosing occupational allergic contact dermatitis: a case report.Annals of occupational and environmental medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Isabella KarlssonDepartment of Environmental Science, Exposure and Effect, Stockholm University, SE-106 91Stockholm, Sweden.ORCID 0000-0002-5924-6123
David J PontingDepartment of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE-412 96Gothenburg, Sweden.ORCID 0000-0001-6840-2629
Miguel A OrtegaDepartment of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE-412 96Gothenburg, Sweden.
Ida B NiklassonDepartment of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE-412 96Gothenburg, Sweden.
Lorena NdreuDepartment of Environmental Science, Exposure and Effect, Stockholm University, SE-106 91Stockholm, Sweden.ORCID 0000-0003-1567-4262
E Johanna L StéenDepartment of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE-412 96Gothenburg, Sweden.ORCID 0000-0002-8707-7574
Tina SeifertDepartment of Chemistry and Molecular Biology, Medicinal Chemistry, University of Gothenburg, SE-412 96Gothenburg, Sweden.
Kristina LuthmanDepartment of Chemistry and Molecular Biology, Medicinal Chemistry, University of Gothenburg, SE-412 96Gothenburg, Sweden.
Ann-Therese KarlbergDepartment of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE-412 96Gothenburg, Sweden.ORCID 0000-0003-2691-3644

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epoxy resin systems (ERSs) are a class of thermosetting resins that become thermostable and insoluble polymers upon curing. They are widely used as components of protective surfaces, adhesives, and paints and in the manufacturing of composites in the plastics industry. The diglycidyl ether of bisphenol A (DGEBA) is used in 75-90% of ERSs and is thus by far the most used epoxy resin monomer (ERM). Unfortunately, DGEBA is a strong skin sensitizer and it is one of the most common causes of occupational contact dermatitis. Furthermore, DGEBA is synthesized from bisphenol A (BPA), which is a petroleum-derived chemical with endocrine-disruptive properties. In this work, we have used isosorbide, a renewable and nontoxic sugar-based material, as an alternative to BPA in the design of ERMs. Three different bis-epoxide isosorbide derivatives were synthesized: the diglycidyl ether of isosorbide (

Indexed as

Epoxy ResinsIsosorbideAnimalsBenzhydryl CompoundsBisphenol A CompoundsEpoxy CompoundsMiceSwineBenzhydryl Compoundsbisphenol ABisphenol A Compoundsbisphenol A diglycidyl etherEpoxy CompoundsEpoxy ResinsIsosorbide

Identifiers

PMID36652206
PMCPMC9945177

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.